Others

Aminooxy-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].

N2-iso-Butyroyl-3'-O-methylguanosine is a Nucleoside Derivative - 3'-Modified nucleoside.

CPI203 (CPI 203) 是一种有效的 BET 溴结构域抑制剂（BRD4 的 IC50：37 nM）。

Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH), leveraging its non-peptide structure for potential therapeutic applications.

MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues to produce a positively charged side chain similar in size to lysine.

Cdc7-IN-19 (compound 1-1) 是一种有效的CDC7抑制剂，对 Cdc7/DBF4 酶的IC50为 1.49 nM。

Ornoprostil, a prostaglandin E1 analogue, acts as a mucosal protectant.

Y 9000 has anti-allergic activity.

STINGagonist-25 (CF505) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING，增加 STING、TBK1和 IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。

Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective agonist for dopamine autoreceptors with potential applications in schizophrenia research [1] [2].

BRD7552 是PDX1转录因子诱导剂，它能够上调人类原代胰岛和导管细胞中 PDX1 的表达，诱导 PDX1 启动子的表观遗传变化与转录激活一致，提高胰岛素表达。其中 PDX1 是参与胰腺发育和β细胞功能的关键转录因子。

B-Raf IN 8 (compound 7g) 是 B-Raf 的有效抑制剂 (IC50 = 70.65 nM)。B-Raf IN 8 显示出抗肿瘤活性，其对肝细胞癌 (HEPG-2)、结肠癌 (HCT-116)，乳腺癌 (MCF-7) 和人前列腺癌 (PC-3) 细胞的 IC50值分别为9.78、13.78、18.52 和 29.85 μM。

Omeprazole magnesium 是口服活性的质子泵（proton pump）抑制剂（PPI），用于抑制胃酸，常用于研究胃酸反流和烧心症相关症状。

Fmoc-PEG24-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

AR-13503, is an metabolite of Netarsudil (AR-11324), is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and​/or reducing intraocular pressure.

CysLT1 leukotriene receptor antagonist

Ibuprofen alcohol, a nonsteroidal antiinflammatory drug (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs).

Clofazimine (Standard) 是一种可用于分析的标准物质，通常用作 Clofazimine 的研究和分析中参考的标准样品。Clofazimine (NSC-141046) 是一种具有显著的抗炎效果的亚氨基酚嗪类染料，与其它抗分支杆菌药物联用来治疗AIDS 和克罗恩病。

1-Penten-3-ol是一种含有双键和羟基的有机化合物，广泛应用于生物化学实验和药物合成研究。

LUF7346 is an allosteric modulator of hERG.

Syk-IN-11 is a selective Syk inhibitor.

Chlorocresol (4-Chloro-3-methylphenol) 是一种医药防腐剂。

AS057278 (3-Methylpyrazole-5-carboxylic acid) 是一种 D-氨基酸氧化酶 (DAAO) 抑制剂。

Antifungalagent 73 (compound A32)是一款用于治疗唑类耐药Candida感染的抗真菌药物。该化合物通过破坏真菌的细胞壁和细胞膜来发挥作用，并且针对病原真菌和氟康唑(Fluconazole)耐药菌株显示出有效的体内抗真菌活性。

Alectinib hydrochloride (Standard) 是一种可用于分析的标准物质，通常用作 Alectinib hydrochloride 的研究和分析中参考的标准样品。Alectinib hydrochloride (RO5424802 Hydrochloride) 是一种有效的、选择性的、口服具有活力的、ATP 竞争性的 ALK 抑制剂，其IC50=1.9 nM，Kd=2.4 nM，并且还抑制ALK F1174L 和ALK R1275Q，其IC50分别为 1 nM 和 3.5 nM。它还有中枢神经系统渗透能力。

19-epi-Scholaricine为一种口服活性吲哚生物碱，具备下调胶原纤维表达和增加超氧化物歧化酶（SOD）活性的特性。

BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hypertensive effects[1].

Plafibride is an antiplatelet and antilipidemic agent.

Terpinolene是一种从多种芳香植物精油中提取的天然单萜，显示出抗增殖和/或细胞毒性效果。它能有效抑制N2a神经母细胞瘤细胞的增殖，并提升原代大鼠神经元的总抗氧化能力(TAC)，同时具备潜在的镇静作用。

4-(Dimethylamino)phenol 能够提高细胞外乳酸脱氢酶(LDH)水平，而对糖异生作用没有显著影响。只有当膜对LDH变得可透性时，4-(Dimethylamino)phenol 才会减少ATP含量。

(Rac)-11-Epicorynoline是一种天然的生物碱，广泛应用于生物化学实验和药物合成研究。

Clinodiside A 是来自中草药Clinopodium chinensis 中。

ALK5-IN-31 是一种 ALK-5 的选择性抑制剂 (IC50≤10 nM)，对 TGF-β 诱导的 SMAD 信号传导也具有抑制作用。ALK5-IN-31 具有抑制体内肿瘤生长的潜力。ALK5-IN-31 可用于研究增殖性疾病（如癌症、纤维化疾病、系统性硬化症）。

PTG-0861 is a highly specific inhibitor of histone deacetylase 6 (HDAC6), demonstrating an impressive IC50 value of 5.92 nm. This compound effectively triggers apoptosis and holds potential for research pertaining to acute myeloid leukemia, multiple myeloma, and other hematological cancers [1].

CPI098 is a potent and selective inhibitors for the bromodomains of CREBBP/EP300. CREBBP/EP300 bromodomains play a critical role in regulatory T cell biology. T cell recruitment to tumors is a major mechanism of immune evasion by cancer cells.

DMT-2'-OMe-Bz-C is a 2'-O-Methyl nucleoside.