Others

Trimipramine N-oxide 为三环抗抑郁药trimipramine的活性代谢物，其对人去甲肾上腺素单胺转运体(hNAT)、血清素(hSERT)、多巴胺(hDAT)以及人体有机阳离子转运蛋白(hOCT1与hOCT2)的IC50值分别为11.7、3.59、9.4、9.35及27.4 nM。因此，Trimipramine N-oxide在忧郁和焦虑研究中有应用价值。

D-Thyroxine (Dextroxin) 是一种甲状腺激素，对 TSH 的分泌具有抑制作用，可用于研究高胆固醇血症。

Terrestroside A是一种天然产物，可用于生物化学实验和药物合成研究。

Hsp90-IN-15 是一种 Hsp90 抑制剂，具有抗癌作用。Hsp90-IN-15 能够将细胞周期阻滞在 S 期，诱导细胞凋亡 (apoptosis)，并可以减少 Hela 细胞中 Hsp90 的表达水平。

MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and reduces the expression of key DNA damage repair genes. Importantly, these effects were demonstrated to be CDK12-dependent as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphorylation and DNA damage repair gene expression. Consistent with its effect on DNA damage repair gene expression, MFH290 augments the antiproliferative effect of the PARP inhibitor olaparib.

Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].

2-Cyanomethylthioadenosine is a Nucleoside Derivative - 2-Modified purine nucleoside.

PCA50941 is a 1,4-dihydropyridine derivative, treatment for cardiovascular disease.

N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

6-Methylbenzo[b]thiophene是一种稠合杂环化合物，广泛应用于生物化学实验和药物合成研究。

N-Desethylsunitinib hydrochloride (Standard) 是一种可用于分析的标准物质，通常用作 N-Desethylsunitinib hydrochloride 的研究和分析中参考的标准样品。N-Desethylsunitinib hydrochloride 是舒尼替尼的主要且具有药理活性的代谢物，是有效的 ATP 竞争性 VEGFR、PDGFRβ 和 KIT 抑制剂。

Sanggenon W（桑根酮 W） 是一种从桑树根皮中提取的异戊烯基黄酮类化合物。

mGlu4 receptor agonist 1 (compound 62) is a highly effective positive allosteric modulator of mGlu4 receptors, displaying an EC 50 of 308 nM. Additionally, it exhibits noteworthy anxiolytic and antipsychotic properties [1].

Topoisomerase I inhibitor 8 是一种喜树碱六环类似物，也是 topoisomerase I 的强效抑制剂，对肿瘤细胞有毒性。

Cephalexin (Cefalexin) hydrochloride monohydrate 是一种口服有效的半合成头孢菌素类抗生素（antibiotic），对广泛的革兰氏阳性及革兰氏阴性细菌展现出抗菌活性。该化合物通过靶向青霉素结合蛋白（PBPs）抑制细菌细胞壁的组装，应用于包括肺炎、链球菌性咽喉炎、细菌性心内膜炎在内的疾病研究。

(R)-Afatinib ((R)-BIBW 2992) 是 Afatinib 异构体。Afatinib 是一种口服有效且不可逆的 ErbB 家族 (EGFR 和HER2) 双特异性抑制剂，对 EGFRwt, EGFRL858R, EGFRL858R/T790M 和 HER2 的 IC50值分别为 0.5 nM、0.4 nM、10 nM 和 14 nM。Afatinib 可用于食管鳞状细胞癌 (ESCC)、非小细胞肺癌 (NSCLC) 和胃癌的研究。

7-Deaza-7-propargylamino-ddGTP 3TEA是一种ddGTP的衍生物和修饰核苷酸，可用于基因测序。ddGTP是Sanger测序中使用的链终止子之一。

Hydroxy-PEG3-NHS is a PEG derivative containing a hydroxyl group with an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. T

HSK16149 是一种新型的电压门控钙离子通道（VGCC）α2δ亚基选择性配体，具有镇痛活性。

PBI-51 is a competitive inhibitor of abscisic acid-regulated gene expression.

ChemR23-IN-3 是一种有效的基于噻唑的ChemR23抑制剂，其IC80值为 12 nM。

Fmoc-NH-PEG16-CH2CH2COOH is a polyethylene glycol (PEG)-based linker, specifically designed for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

LU32-176B is a bioactive chemical.

IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.

CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.

SPK-601 is an inhibitor of phosphatidylcholine-specific phospholipase C.

Vonifimod 是一种免疫调节剂。

YKL-5-124 TFA是一种高效、选择性不可逆的CDK7共价抑制剂，具有53.5 nM对CDK7的IC50值和9.7 nM对CDK7/Mat1/CycH的IC50值。此化合物对CDK7的选择性超过CDK9和CDK2 100倍以上，对CDK12和CDK13则无活性。YKL-5-124 TFA能显著诱导细胞周期停滞，抑制E2F驱动的基因表达，对RNA聚合酶II的磷酸化状态影响微乎其微。

2-Hydroxyalbrassitriol (Compound 6) 是一种AChE 抑制剂，IC50为 35.97 μM。

EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively. EMT inhibitor-2 inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes.

Sodium 1-heptanesulfonate monohydrate是可用于离子对色谱的试剂，可用于分析多肽和蛋白质等生物分子。

endo-BCN-PEG6-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Glycogen phosphorylase-IN-1 是一种具有选择性和高效性的人肝糖原磷酸化酶 (hlGPa) 抑制剂 ，对 hlGPa 活性和和肝细胞糖原衍生葡萄糖的生成有抑制作用，可用于研究 2 型糖尿病和犬类狼疮。

Metaldehyde (Metacetaldehyde) 是一种农业中使用的软体动物杀灭剂，可在细胞中诱导 DNA 片段化。

KM04416 是一种 GPD2 抑制剂，通过调节免疫细胞浸润来抑制 LUAD 进展。

(S)-BI 665915 is an orally active inhibitor of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP)(IC50 of 1.7 nM for FLAP binding)..