Others

pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.

cIAP1 Ligand-Linker Conjugates 15 hydrochloride is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is useful in the development of SNIPERs[1].

ML-178 是一种二氯苯，是鞘氨醇-1-磷酸受体4（S1PR4）的强效选择性激动剂，EC50 为 46 nM，在25 μM 的浓度下对其他 S1P 受体没有影响。

(R)-Carvedilol is a non-selective blocker of β/α-1. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

Oleylamine(油胺）是一种长链伯胺，具有表面活性剂的特性，在工业中用途广泛，溶于多种有机溶剂且不溶于水。cis-1-Amino-9-octadecene用于控制纳米粒子的形态并防止聚集和将金属前体还原为金属纳米粒子。

N-Boc-PEG36-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Docetaxel (Standard) 是一种可用于分析的标准物质，通常用作 Docetaxel 的研究和分析中参考的标准样品。Docetaxel (RP-56976) 是紫杉醇的半合成类似物，是一种微管解聚抑制剂 (IC50=0.2 μM)。Docetaxel 可以减弱 bcl-2 和 bcl-xL 基因表达的影响，具有诱导凋亡、抗肿瘤活性。

(±)-H3RESCA-TFP is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA).

protein kinase C (PKC) inhibitor

lsocryptomerin 是一种具有膜活性的抗真菌 (antifungal) 化合物，可从 Selaginella tamariscina 中分离得到。lsocryptomerin 能使真菌质膜去极化。lsocryptomerin 还具有抗癌和抗细菌 (antibacterial) 活性。

Compound C108是 GTPase 激活蛋白 SH3 结构域结合蛋白 2 (G3BP2) 的抑制剂。 Compound C108可用于乳腺肿瘤和食管鳞状细胞癌的研究。

MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.

(2E,4E)-Decadienoic acid 是一种抗卵菌脂肪族化合物，存在于 Bacillus subtilis 和 Trichoderma asperellum 的共培养物中。

Triacetyl-β-cyclodextrin是一种羟基经过乙酰化修饰的β-环糊精，可用于药物包封和缓释等生化实验。

ATR-IN-9 is a highly effective inhibitor of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). With an IC50 value as low as 10 nM, ATR-IN-9 demonstrates exceptional potency.

6-Chloropurine (6-Chloro-9H-purine) 是一种制备9-烷基嘌呤和6-巯基嘌呤的中间体，是化学合成的砌块，具有抗肿瘤作用。

Niclofolan, a biphenyl anthelmintic compound, is used orally towards the treatment of Fasciola hepatica infection.

L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 µM for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response

PDE4-IN-10 (compound 7a) 是一种有效的PDE4抑制剂，其对PDE4B 的IC50值为 7.01 μM。PDE4-IN-10 表现出选择性，微粒体稳定性，对TNF-α有抑制作用，并且在体外无明显毒性。

2-(2-Methylbenzamido)acetic acid (Standard) 是一种可用于分析的标准物质，通常用作 2-(2-Methylbenzamido)acetic acid 的研究和分析中参考的标准样品。2-(2-Methylbenzamido)acetic acid (O-Toluric acid) 是一种能够在尿液中检测到的代谢物。

Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally.

Dacarbazine ( imidazole carboxamide) is a chemotherapy drug used to treat melanoma and Hodgkin's lymphoma.

DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tumor growth. Furthermore, DNA-PK-IN-3 demonstrates remarkable efficacy in reducing damage to normal cells, effectively minimizing adverse side effects. Due to these compelling properties, DNA-PK-IN-3 holds great potential for cancer research applications[1].

(Rac)-RK-682 是 RK-682 的外消旋体。(Rac)-RK-682 是一种蛋白质酪氨酸磷酸酶 (PTPases) 抑制剂。(Rac)-RK-682 抑制蛋白酪氨酸磷酸酶 1B (PTP-1B)、低分子量蛋白酪氨酸磷酸酶 (LMW-PTP)、细胞分裂周期 25B (CDC-25B)，IC50分别为 8.6 μM、12.4 μM 和 0.7 μM。

Bromodomain inhibitor-9 是Bromodomains 抑制剂，可选择性抑制 BRD4-1的活性，其 Kd 值为 12 nM。Bromodomain inhibitor-9 能够用于与全身或脂质代谢、组织炎症、纤维化或慢性自身免疫性疾病相关疾病的研究。

Ilexhainanoside D 是Ilex hainanensis Merr中分离提取的主要三萜皂苷类成分，当该成分与Ilexsaponin A1联合应用时，可发挥显著的抗炎活性。

Maximiscin 是一种真菌代谢产物，可诱导DNA damage 损伤，并对一种三阴性乳腺癌亚型显示出选择性的细胞毒活性。

Dimethylamino-PEG2-C2-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Varespladib sodium (LY315920 sodium) is a highly potent and selective inhibitor of group IIA secretory phospholipase A2 (sPLA2), with an IC50 of 9 nM. It demonstrates significant inhibitory activity against sPLA2 in serum samples from multiple species, including rat, rabbit, guinea pig, and human, with IC50 values of 8.1 nM, 5.0 nM, 3.2 nM, and 6.2 nM, respectively.

AM-Imidazole-PA-Boc is an alkyl chain-derived PROTAC linker utilized for the synthesis of PROTAC IRAK4 degrader-1[1].

N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a polyethylene glycol (PEG)-based linker for the development of proteolysis targeting chimeras (PROTACs)[1].

Ceritinib (Standard) 是一种可用于分析的标准物质，通常用作 Ceritinib 的研究和分析中参考的标准样品。Ceritinib (LDK378) 是一种 ALK 酪氨酸激酶抑制剂 (IC50=200 pM)，具有选择性、ATP 竞争性和口服活性。Ceritinib 还可以抑制 IGF-1R、InsR 和 STK22D (IC50=8/7/23 nM)。Ceritinib 具有抗肿瘤活性。

L-threo-PPMP is an inhibitor of GlcT, which is the UDP-Glc: Ceramide β1,1glucosyltransferase enzyme. It effectively inhibits glycosphingolipid biosynthesis, while also inducing apoptosis. These properties of L-threo-PPMP contribute to its notable anti-cancer activity.

Laninamivir Octanoate Monohydrate is a neuraminidase inhibitor.

L-Luciferin是萤火虫luciferase的竞争性抑制剂和发光底物，可以被酶/辅因子系统转化为D-Luciferin。

Boc5 is an GLP-1R agonist.