Antibacterial

LL D05139(beta) is an novel antitumor antibiotic agent.

Marasmic acid is a bioactive antifungal.

Lankacidinol A is a metabolite of macrolide antibiotic.

Lankacyclinol A is a Lankacidin antibiotic.

Altromycin E is a new pluramycin-like antibiotic.

Altromycin F is a new pluramycin-like antibiotic.

Piperic acid is a powerful antioxidant and has potent antibacterial properties

Rubradirin is an antibiotic with a complex chemical structure that is active vs. methicillin resistant staphylococci. It is a selective enzymatic peptide initiation inhibitor.

A 83016A is a kinamycin-type antibiotic.

Racemomycin B is a beta-lysine-rich streptothricin antibiotic.

Rabelomycin is an angucycline group antibiotic.

FOL7185 is an inhibitor of IspD and IspE enzymes isolated from bacteria.

Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity.

Furalazine is an antimicrobial agent. Furalazine was more effective in reducing the duration of positive stool culture than chloramphenicol. It may be potentially used in the treatment of cholera.

MAC-0547630 potent and selective inhibitor of UppS.

BTZ-N3 is an effective and selective anti-tuberculosis drug candidate.

BK 218 is a novel cephalosporin, which is active against streptococcus pneumoniae, Haemophilus influenza, and Moraxella catarrase, but has a higher MIC against penicillin-resistant strains. Bk-218 has dual administration routes and the activity spectrum m

Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybridsJ. Am. Chem. Soc.129(18)6022-6030(2007) 2.Aoyama, T., Kojima, F., Yamazaki, T., et al.Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activitiesJ. Antibiot. (Tokyo)46(5)712-718(1993)

10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and teniposide and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 μg/ml, respectively). 10'-Desmethoxystreptonigrin is also an inhibitor of p21ras farnesylation (IC50 = 21 nM).

Alamethicin F50 is a peptaibol isolated from Trichoderma. It is a polymer of 20 amino acids that includes modified and non-proteinogenic amino acids. Alamethicin F50 is a mixture of 13 different peptides, with the most abundant designated as alamethicin F50/5. Alamethicin F50 forms voltage-dependent ion channels in lipid membranes and acts as a lytic agent. It induces lysis of leukocytes (IC50 = 54 and 80 μM for rat mast cells and mouse spleen lymphocytes, respectively) and exhibits antibacterial activity against a panel of 8 mollicutes (MICs = 1.56-12.5 μM).

Flambalactone is a degradation product formed by methanolysis of the antibiotic flambamycin.

Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens.

CAY10742 is an orally bioavailable oxadiazole antibiotic.1It is active against the Gram-positive bacteriaS. aureus,S. epidermidis,S. haemolyticus,B. cereus,B. licheniformis,E. faecalis, andE. faecium(MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistantS. aureus(MRSA) infection. 1.Boudreau, M.A., Ding, D., Meisel, J.E., et al.Structure-activity relationship for the oxadiazole class of antibacterialsMed. Chem. Lett.11(3)322-326(2019)

T145 inhibits growth of Enterococcus faecalis, Staphylococcus aureus and Mycobacterium tuberculosis (Mtb) with sub μg/ml potencies that are potentially therapeutically valuable. T145 minimizes selection of spontaneous resistant mutants, a trait that prolo

Primidolol is a beta adrenergic receptor antagonist and antihypertensive agent.

Mycobactin P is one of iron(III) chelating compounds produced by most species of Mycobacteria which act as growth factors.

PD 116152 is a highly substituted phenazine with antitumor activity isolated from the culture broth of a Streptomyces sp. The antitumor activity versus murine P388 leukemia is T/C 149. PD 116152 is selectively active versus the bacterium Streptococcus pne

Methenamine mandelate-loaded nanoparticles can induce DNA damage and apoptosis of cancer cells.

LL-C 10037alpha is a gamma-aminoepoxysemiquinone isolated from Streptomyces.

Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

cOB1 pheromone是一种细菌性信息素，其对多重耐药粪肠球菌V583表现出有效抑制作用。

Allergen Gal d 4 (46-61), chicken, is a peptide derived from hen egg white lysozyme.

S-Thanatin 是一种昆虫抗菌肽，具有广谱、强效抗菌活性。S-Thanatin 能抑制革兰氏阴性菌、革兰氏阳性菌和真菌的活性，且无细胞毒性。其抗菌活性不受 PH 值影响，但单价阳离子 (Na+/K+) 会以剂量依赖方式降低其对革兰氏阴性菌的抑菌活性。

Bombinin-Like Peptide (BLP-1) is an antimicrobial peptide derived from species of the genus Bombina.

RW3 是一个小型阳离子六肽，呈两亲性，通过靶向细菌细胞质膜来发挥作用，抑制细胞呼吸和细胞壁合成。RW3 对革兰氏阳性细菌表现出卓越的生物活性，同时在早期研究中未显示明显的细胞毒性或溶血作用。在两倍最小抑制浓度 (MIC) 下，RW3 能在10分钟内迅速杀灭97%的初始菌落形成单位 (CFU)。它可用于抗微生物和抗真菌研究。

Lactoferrin 17-41 (Lactoferricin B) acetate，即牛乳铁蛋白残基17-41，展现出对革兰氏阳性与阴性细菌、病毒、原生动物及真菌等多样微生物的抗菌作用，并且具备抗肿瘤活性。