Antibiotic

Carbazomycin B is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against a panel of seven fungi and a panel of seven bacteria, as well as P. falciparum and C. albicans. It is also active against a panel of five plant pathogenic fungi. Carbazomycin B is cytotoxic to MCF-7, KB, NCI H187, and Vero cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts (IC50 = 1.5 µM).

LL-BM123α 是一种从诺卡菌分离出的碱性抗生素，对革兰氏阴性菌具有适度活性。

Protorubradirin 是一种可以从不产色链霉菌红紫灵变种中与 Rubradirin 分离得到的抗生素。Protorubradirin 对 HIV 逆转录酶具有抑制活性，并在体外研究中抑制金黄色葡萄球菌菌株和链球菌。在小鼠感染模型中，皮下注射 Protorubradirin 对抗生素耐药的金黄色葡萄球菌表现出较强的体内抑制效力，但口服可能显著降低其活性，可能是由于其 C-亚硝基糖在酸性胃环境中的裂解速度更快。

Aranciamycin A 是一种从链霉菌中提取的蒽环类抗生素，对牛分枝杆菌和枯草芽孢杆菌表现出抗菌活性，最低抑菌浓度（MIC）分别为30 µM和7.5 µM。

Cefempidone (GR 50692) 是第三代头孢菌素类抗生素，通过抑制细菌细胞壁合成中的青霉素结合蛋白来实现抗菌效果。

Cetefloxacin (E 4868) 是广谱抗菌抗生素，MIC范围为0.007-8 µg/ml。在小鼠体内，Cetefloxacin 显示出优良的药代动力学特性，并对Escherichia coli、Pseudomonas aeruginosa、Staphylococcus aureus和Streptococcus pneumoniae具保护作用。

Mucidin 是一种抗真菌抗生素，能够抑制线粒体呼吸链中细胞色素 bc1 复合物的电子传递过程。

Rubiginone D2 是一种抗生素，能够抑制Bacillus subtilis、Staphylococcus aureus和Escherichia coli的活性。同时，Rubiginone D2 还具有抗癌能力，可阻止癌细胞HM02、Kato III、HepG2和MCF7的增殖，GI50分别为0.1、0.7、<0.1和7.5 μM。

Mazethramycin是一种抗肿瘤抗生素，能够通过干扰细胞的DNA复制及RNA合成来实现其抗癌效果。Mazethramycin可应用于癌症研究领域。

Mandelonitrile benzoate is a biochemical.

Demeclocycline calcium is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.

D-Cystine, the D-enantiomer of L-Cystine, functions as an inhibitor of L-aspartate-β-semialdehyde dehydrogenase (ASADH) derived from Escherichia coli.

PKUMDL-LTQ-301 is a potent inhibitor of HipA toxin. PKUMDL-LTQ-301 also inhibits E. coli persistence.

Y 12896 在生命科学相关研究中具有广泛的应用。

Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50s = <0.09-1.78, 0.44-3.63, and 2.31-5.2 mg/animal, respectively). Formulations containing cefazolin have been used to treat a variety of bacterial infections.

Chlortetracycline is an analog of tetracycline , a broad spectrum antibiotic. In addition to its actions against microorganisms, chlortetracycline suppresses inflammation by inhibiting neutrophil action and other aspects of the innate immune response. 4-epi-Chlortetracycline is an epimer of chlortetracycline.

Leucomycin A13 is a macrolide antibiotic and a component of the leucomycin complex originally isolated from S. kitasatoensis. It is active against B. subtilis, S. aureus, M. luteus, and E. coli with MIC values of 0.16, 0.16, 0.08 and >10 μg/ml, respectively. It binds to ribosomes with an IC50 value of 1.2 μM in a radioligand binding assay.

10-Norparvulenone is a fungal metabolite originally isolated fromMicrosphaeropsis.1It decreases viral sialidase activity in, and increases survival of, MDCK cells infected with the mouse-adapted influenza virus A/PR/8/34 when used at a concentration of 1 μg/ml. 1.Fukami, A., Nakamura, T., Kim, Y.P., et al.A new anti-influenza virus antibiotic, 10-norparvulenone from Microsphaeropsis sp. FO-5050J. Antibiot. (Tokyo)53(10)1215-1218(2000)

Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis.

Clavicoronic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.

Diclazuril K is a coccidiostat and GAPDH inhibitor used to prevent parasitic contamination of livestock and poultry feed.

Josamycin HCl is a macrolide antibiotic.

Gepotidacin hydrochloride, also known as GSK-2140944 hydrochloride, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin hydrochloride is a novel antibacterial drug candidate. Gepotidacin hydrochloride Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin hydrochloride is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, Gepotidacin hydrochloride inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

(-)-(E)-α-Atlantone为Artemisia vestita油中的挥发性组分。

4-Oxo-5-phenylpentanoic aci 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125056，CAS号为 3183-15-1。

Granatomycin B 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124348，CAS号为 71203-18-4。

Sarubicin A (U-58431) 是一种抗生素，能够抑制革兰氏阳性和阴性细菌，并且具有抗肿瘤活性。

AFK-108 is a fungicide agent.

Deoxypheganomycin D is a specific mycobacteria inhibitor.

Acediasulfone is an antibiotic. It is used to treat ear infections.

DA 1131 is a new carbapenem antibiotic. It undergoes renal metabolism by renal dehydropeptidase I.

Erythromycin glutamate is a macrolide bacteriostatic antibiotic. This antibiotic is metabolized through the liver and inhibits cytochrome enzyme P450A 3A41.

Acyclovir hydrochloride (Aciclovir)，一种口服抗病毒药物，展现出显著的抗疱疹效果。该化合物对HSV-1和HSV-2显示出较低的IC50，分别为0.85 μM和0.86 μM。此外，Acyclovir hydrochloride能够引起细胞周期的干扰及诱导凋亡 (apoptosis)。它还用于预防在急性白血病的诱导治疗中发生的细菌感染。

Miloxacin is an antibiotic active against gram-negative bacteria.

Levonadifloxacin, a broad-spectrum fluoroquinolone antibiotic, is used potentially for the treatment of staphylococci.

Antibiotic K 4 is an inhibitor of angiotensin I converting enzyme produced by Actinomadura spiculosospora.