Antibiotic

4-Aminobenzimidamide Hydrochloride (Compound 4a) 作为MRGPRX1的激动剂, 主要应用于研究MRGPRX1介导的镇痛效果。

(3S)Lenalidomide-piperazine-C-piperidine' 是E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 中的一种。该化合物可用作合成PROTAC ER Degrader-11 的原料。

Carbonic Anhydrase Inhibitor28 (Compound 11) 作为一种有效的Pseudomonas aeruginosa碳酸酐酶抑制剂，展现出良好的抑菌活性。具体来说，其对P. aeruginosa 的最小抑菌浓度(MIC)为0.5 μg/mL，最小杀菌浓度(MBC)为1 μg/mL。因此，Carbonic Anhydrase Inhibitor28 在抗感染研究领域具有潜在应用价值。

CPPD-Q 是一种用于抑制细菌和杀灭昆虫的化合物。对 Vibrio fischeri 的 EC50 为 6.98 mg/L。CPPD-Q 在 1 或 10 µg/mL 的剂量下，通过诱导秀丽隐杆线虫 (Caenorhabditis elegans) 肠道产生活性氧 (ROS) 来实现其杀虫效果。

BU-2313 A is a new antibiotic complex. It also active against anaerobes.

PF-04064900 is a prodrug of sulopenem penem antibiotic.

Avenacein Y is a biochemical.

Basacv is a bisacridinyl peptidic analog of triostin A.

Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimuriu

Piampicillin Hydrochloride is a Hydrochloride form of an oral active ampicillin new spray with antimicrobial activity.

Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.

N-(3-(Dimethylamino)propyl)tetradecanamide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66531，CAS号为 45267-19-4。

(5-Nitrofuran-2-yl)methylene diacetate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66265，CAS号为 92-55-7。

N-3-hydroxydecanoyl-DL-Homoserine lactone is a bacterial quorum-sensing molecule.1It activates SdiA (EC50= 0.6 μM), a transcription factor that detects N-acyl homoserine lactones (AHLs), in the 14028/pJNS25 strain ofS. enterica.2 1.Fekete, A., Frommberger, M., Rothballer, M., et al.Identification of bacterial N-acylhomoserine lactones (AHLs) with a combination of ultra-performance liquid chromatography (UPLC), ultra-high-resolution mass spectrometry, and in-situ biosensorsAnal. Bioanal. Chem.387455-467(2007) 2.Janssens, J.C.A., Metzger, K., Daniels, R., et al.Synthesis of N-acyl homoserine lactone analogues reveals strong activators of SdiA, the Salmonella enterica serovar Typhimurium LuxR homologueAppl. Environ. Microb.73(2)535-544(2007)

Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-dependently increases the mortality of adult C. chinensis weevils up to 100% and has mitogenic activity against T. telarius when sprayed onto plants with an LC50 value of 9.2 μg/ml. It reduces IL-1β- and cAMP-induced secretion of phospholipase A2 (PLA2) from rat mesangial cells (IC50s = 43 and 33 nM, respectively). Tetranactin (50 ng/ml) suppresses the proliferation of human T lymphocytes induced by allogeneic cells and IL-2 and supresses the generation of cytotoxic T lymphocytes in mixed lymphocyte cultures. In vivo, tetranactin (10 mg/animal per day) completely inhibits the formation of experimental autoimmune uveoretinitis (EAU) in rats.

Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus. It is active against S. aureus when used at a concentration of 32 μg/ml. Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 μg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg. Gilvocarcin M intercalates into bacteriophage PM2 DNA. It is toxic to rats with an intravenous LD50 value of 450 mg/kg.

Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria. [1]. Apramycin, From Wikipedia

Leucomycin A4 is a macrolide antibiotic that has been found in S. kitasatoensis. It is active against a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 μg/ml, respectively).

D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is a crucial raw material in the synthesis of semisynthetic β-lactam antibiotics, including Amoxicillin and Cefadroxil .

Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. Note: Streptonigrin from natural resource is (-)-rotation, has CAS#3930-19-6 and is a R-isomer.

(-)-cis-Myrtanol, 一种源于Artemisia dracunculus的萜类化合物，表现出对Bifidobacterium bifidum等肠道有害细菌的有效抗菌活性。

Destomycin A 是一种具备多重生物活性的氨基糖苷类抗生素，能有效对抗革兰氏阳性菌及革兰氏阴性菌，同时具有抗真菌和驱虫的特性。此外，Destomycin A 可抑制 Escherichia coli 细胞中的多肽合成，并能激活动物组织内的腺苷酸环化酶。

ISOPLUMBAGIN，一种来源于无刺指甲花(Lawsonia inermis)和欧洲血根草(Plumbago europaea)的天然产生的醌类化合物。这种化合物已被报道具有抗炎和抗微生物的活性。

Musellactone shows different effects against five bacteria strains.

Bac8c 为一种高效的抗菌肽，其对革兰氏阴性及阳性菌均展现出显著的抗菌效力。针对S. aureus、MRSA、S. epidermidis、E. coli 及 P. aeruginosa，Bac8c 的最小抑菌浓度(MIC)分别为 2 μg/mL、8 μg/mL、4 μg/mL、4 μg/mL、4 μg/mL。

Polyoxin D (zinc) (Polyoxorim (zinc)) ，多抗霉素类抗生素杀真菌剂，是几丁质合成酶 (chitin synthetase) 的有效抑制剂。

Monamycin V 是一种酯肽抗生素，对革兰氏阳性菌表现出活性。

Pluracidomycin A2 (PLM A2) 是一种碳青霉烯类抗生素，具备对革兰氏阳性菌和革兰氏阴性菌的活性。

Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It also inhibits proliferation in a panel of additional cancer cell lines (IC50s = <0.01 μM).

Cyclamidomycin is an antibiotic. It also functions as an inhibitor of nucleoside diphosphokinase of Escherichia coli.

Aquayamycin is an anthraquinone derivative and inhibitor of the enzyme tyrosine hydroxylase..

Frenolicin B 是一种抗生素。

Fmoc-L-photo-proline为可通过Fmoc固相法纳入合成肽中的光交联氨基酸。该化合物在环状拟肽抗生素合成及肽基光亲和探针研究制备中应用广泛。

Pyrromycin is a monosaccharide anthracycline which can be used to inhibit cellular RNA synthesis.

Fabimycin 是一种FabI 抑制剂，对革兰氏阴性菌具有有效的抗菌活性。Fabimycin 可抵抗耐药性革兰氏阴性菌感染 (in vivo)。