Others

ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), effectively targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s, belonging to the disulfide-rich, Ca2+-dependent enzyme family, catalyze the hydrolysis of glycero-phospholipids at the sn-2 position, resulting in the release of a fatty acid and a lysophospholipid. ROC-0929 holds promise in researching inflammation-related diseases.

GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects, with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin. GPVI is a major collagen receptor on platelets, making it an ideal target for safe and effective antithrombotic treatment. Therefore, GPVI antagonist 3 holds potential as a novel antiplatelet agent [1].

TCO-PEG3-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Precyasterone 是一种天然产物，分离自 Cyathula capitata 干燥的根中。

Nucleoside Derivatives - Azido-nucleosides, 3'-Modified nucleosides

BAY-771是一种BAY-069的阴性对照和结构类似物，在Caco-2细胞中具有高渗透性，对BCAT1具有极弱的抑制活性，对BCAT2无活性。BAY-069是一种BCAT1/2抑制剂和化学探针，用于研究癌症和支链氨基酸代谢。

C24 dihydro Ceramide (d18:0/24:0) (Standard) 是一种可用于分析的标准物质，通常用作 C24 dihydro Ceramide (d18:0/24:0) 的研究和分析中参考的标准样品。C24 dihydro Ceramide 是一种鞘脂类物质，存在于人类皮肤的角质层中。与男性皮脂相比，女性皮脂中的 C24 dihydro Ceramide 含量更高。

Vocacapsaicin (CA-008), a prodrug of Capsaicin and a first-in-class non-opioid TRPV1 agonist, offers significant and enduring pain relief.

CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the

Cinromide (trans-3-Bromo-N-ethylcinnamamide) 是抗惊厥药，能够抑制上皮中性氨基酸转运蛋白 B0AT1 (SLC6A19)，其 IC50=0.5 μM。

Ac4GlcNAz(N-叠氮基乙酰葡糖胺四酰化)是一种细胞渗透性的叠氮官能化标记物，其天然单糖对应物为GlcNAc，能够通过点击化学进行后续纯化或引入荧光基团来观察糖缀合。

Cyclo(L-Phe-trans-4-hydroxy-L-Pro) (Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline))是一种存在于Phellinus igniarius 中的天然产物。

N-(Biotin-PEG4)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker molecule employed in the synthesis of PROTACs[1].

Carumonam, an antibiotic, could enhance the reactivity of Escherichia coli with mono- and polyclonal antisera to rough Escherichia coli J5.

Hydroxy-PEG5-C2-methyl ester is a polyethylene glycol (PEG) derived linker compound employed in PROTAC (PROteolysis TArgeting Chimeras) synthesis[1].

Ocedurenone, a corticosteroid receptor antagonist, is a compound utilized in the investigation of kidney disease (WO2018054357, compound I).

FWM-3是一种有效的 SARS-CoV-2 NSP13解旋酶抑制剂。

ζ-Stat trisodium (NSC37044 trisodium) is a potent and selective inhibitor of protein kinase C-ζ (PKC-ζ), exhibiting an IC50 of 5 μM. It effectively suppresses the proliferation of melanoma cell lines and promotes apoptosis. Moreover, ζ-Stat trisodium demonstrates notable antitumor activity in vitro.

GABAA receptor inverse agonist

4-(10,15,20-Triphenyl-21H,23H-porphin-5-yl)benzenamine是一种卟啉衍生物，主要用于光化学和材料科学研究。

Pomalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand based on Pomalidomide with a linker. This compound is instrumental in designing PROTAC BRD4 Degrader-1[1].

κ receptor antagonist

Kelatorphan is an enkephalin degrading enzyme full inhibitor.

Sebetralstat (KVD900) 是一种血浆激肽释放酶抑制剂，可用于代谢性疾病的研究。

Methyl 2-(1H-indol-3-yl)acetate (Standard) 是一种可用于分析的标准物质，通常用作 Methyl 2-(1H-indol-3-yl)acetate 的研究和分析中参考的标准样品。苹果中含有 Methyl 2-(1H-indol-3-yl)acetate。它是从海豌豆(Lathyrus maritimus)、紫豆(Vicia amurensis)、野生大豆(Glycine soja)、野豆(Vigna catiang var. sinensis)和风信子豆(Dolichos lablab)的未成熟种子中分离得到的。Methyl 2-(1H-indol-3-yl)acetate 具有抗肿瘤活性。

PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.

2-Amino-6-methythio-9-(beta-D-ribofuranosyl)-9H-purine is a Nucleoside Derivative - 6-Modified purine nucleoside; Thio-nucleoside.

3-(5-Methylfuran-2-yl)propanoic acid是一种合成的非蛋白源性氨基酸，其特征是具有标准的三碳丙酸骨架，α碳（C2）处有一个氨基官能团（-NH2），β碳（C3）处有一个独特的5-甲基呋喃-2-基取代基。其中呋喃环——一个含氧原子的五元芳香杂环,提供了其独特的结构和电子特性。

BRD9092 是一种小分子探针，可升高氧化应激标志物而不会导致细胞死亡。

PI3K-IN-35 (Compound 6l) 是一种 PI3K 的高选择性抑制剂，作用于 PI3K-α (IC50: 13.98 μM)、PI3K-β (IC50: 7.22 μM) 和 PI3K-δ (IC50: 10.94 μM)。PI3K-IN-35 可将细胞周期阻滞于 G2/M 期，并诱导细胞凋亡。PI3K-IN-35 能够用于研究白血病。

2-Methyl-3-heptanone（2-甲基-3-庚酮）是一种酮，常用于香料制备、有机合成和生化实验。

DL-Metanephrine-d3 Hydrochloride 是用氘原子标记的 L-Metanephrine，可用于研究 L-Metanephrine 在身体内的代谢流程。

(2R)-Glycerol-O-β-D-Galactopyranoside是肠道细菌的乳糖操纵子（lac operon）的天然底物,对RAJI细胞具有抑制效果，广泛应用于生物化学实验和药物合成研究。

Phenolphthalol 显示出雌激素活性，它在药物制剂中也是一种缓泻剂。

“(2,4-Dichloro-3,5-dimethoxyphenyl) methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside (化合物 2)” 是源自Lilium regale的抗癌化合物，其对A549肺癌细胞表现出显著的抑制作用，具有29 μM的IC50值，因此适用于癌症相关的生物医学研究。