Parasite

Ivermectin B1a 是 Avermectin B1a 的一种衍生物，是 Ivermectin 的主要成分。Ivermectin 是广谱的抗寄生虫剂。Ivermectin 也是抗 SARS-CoV-2/COVID-19 的候选药物。

Spinosyn Daglycone (A-83543D aglycone) 是杀虫剂 Spinosyn D 的苷元形式。不同于 Spinosyn D，Spinosyn D 苷元对 H. virescens（烟芽虫）新生幼虫无毒（LC50=>64 ppm）。

FR900098 是一种抗疟剂，能够抑制 1-脱氧-d-木酮糖-5-磷酸 (DXP) 还原异构酶。FR900098 不具有显著的急性毒性和遗传毒性，也不具备导致染色体断裂或非整倍体的能力。此化合物对 NMRI 小鼠的骨髓红细胞无影响。

Pentamidine dimesylate is an inhibitor of calcium-dependent complex formation with p53 [(Ca)S100B-p53) in malignant melanoma (MM). Pentamidine dimesylate restores p53 tumor suppressor activity in vivo.

(S)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine shows efficiently inhibits SARS-CoV-2 infection in vitro.

1R-cis-Permethrin为一种杀虫剂以及神经毒素，主要通过延长钠通道激活来影响神经元膜。

CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.

Glycobiarsol is used for the control of Trichuris vulpis infection.

Narasin (sodium salt) (HainanMycin) 通过神经胶质瘤细胞中的 ER 应激诱导肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 介导的细胞凋亡，并通过抑制 IκBα 的磷酸化来抑制 NF-κB 信号传导。

Flubendazole-D3 (methyl-D3)是Flubendazole (<a style="color:#E14C54" href="/compound/flubendazole">T0009</a>)的氘代化合物。Flubendazole的CAS号为31430-15-6。Flubendazole是用于治疗人类蠕虫感染的驱虫药。它通过抑制微管功能等机制发挥抗癌作用。它诱导p53介导的细胞凋亡，抑制 G2/M 细胞周期。

Urethane-D5是Urethane (<a style="color:#E14C54" href="/compound/urethane">T0051</a>)的氘代化合物。Urethane的CAS号为51-79-6。Urethane是多种食品中发酵形成的副产物，是氨基甲酸的乙酯，具有抑制细菌、海胆卵、原生动物和植物组织生长的作用。

Chloroquine-D5 diphosphate是Chloroquine diphosphate (<a style="color:#E14C54" href="/compound/chloroquine%20phosphate">T0194</a>)的氘代物。Chloroquine phosphate是一种常用于治疗疟疾和类风湿性关节炎的抗疟疾和抗炎药。其为autophagy和toll-like receptors (TLRs)的抑制剂，并能够有效抑制SARS-CoV-2 (COVID-19)感染。

Dapson-13C12是Dapson (<a style="color:#E14C54" href="/compound/dapsone">T0891</a>)的 13C 的标记化合物。

Artemether-D3是Artemether (<a style="color:#E14C54" href="/compound/artemether">T1323</a>)的氘代形式。Artemether作为抗疟疾的化合物，能够对抗耐药的恶性疟疾菌株。

Thiabendazole-D4是Thiabendazole (<a style="color:#E14C54" href="/compound/thiabendazole">T0938</a>)的氘代化合物。

Hydroxychloroquine sulfate (Acidum iopanoicum) 抑制疟原虫血红素聚合酶。它还可抑制 Toll 样受体 7/9 信号传导和 SARS-CoV-2 感染。

Albendazole sulfoxide-D3 is deuterium-labeled Albendazole sulfoxide. Albendazole sulfoxide (<a style="color:#E14C54" href="/compound/albendazole%20sulfoxide">T6372</a>) is a broad-spectrum anthelmintic.

Metronidazole-D3是Metronidazole (<a style="color:#E14C54" href="/compound/metronidazole">T1079</a>)的氘代化合物。

Albendazole-D7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole (<a style="color:#E14C54" href="/compound/albendazole">T1152</a>) is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths,including liver flukes,tapeworms,and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (<a style="color:#E14C54" href="/compound/albendazole">T1152</a>) (0.05% in the diet)protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM),halts the cell cycle at the G2/M phase,and induces apoptosis. In an HT-29 mouse xenograft model,it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally. Albendazole (<a style="color:#E14C54" href="/compound/albendazole">T1152</a>)inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole t......

Robenidine-D8 hydrochloride是Robenidine hydrochloride 的氘代化合物。Robenidine Hydrochloride (<a style="color:#E14C54" href="/compound/robenidine%20hydrochloride">T2549</a>)的CAS号为25875-50-7。

Piperazine (1,4-Diazacyclohexane) 作为γ-氨基丁酸 (GABA) 激动剂，扮演着重要角色，是许多具不同药理活性药物中关键的核心成分。

2'-Hydroxy-5'-methoxyacetophenone (5-Methoxy-2-hydroxyacetophenone) 是一种活性生化剂。

3-Butylidenephthalide (Butylidene phthalide) 是从 Ligusticum chuanxiongHort 鉴定出的一种邻苯二甲酸酐衍生物，有杀虫活性。

1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2480，CAS号为 113558-03-5。

Glycerol 1-(26-hydroxyhexacosanoate) has weak activities antiplasmodial

Santonin (alpha-Santonin) 是Artemisia cina 的活性成分，可用于研究蠕虫感染。它是一种有效的抗寄生虫剂。

Ile-AMS is active in P. falciparum, with an ABS IC50 of 1.19 nM [1].

5'-Deoxy-5'-methylthioadenosine-D3是内源性核苷代谢物5'-脱氧-5'-甲基硫代腺苷 (MTA，CAS 2457-80-9）的稳定氘标记类似物。该化合物保留了母体分子的肿瘤细胞增殖抑制效应，主要作为质谱代谢组学研究中的内标物，用于定量生物样品中的MTA水平。

Methyl 6-hydroxyangolensate shows antifungal and antibacterial activities.

Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, selectivity index > 217).

Niranthin 是一种木脂素，具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂，可用于研究耐药利什曼病的治疗。

D-arabinose 是内源性代谢产物的一种。

Artemether (CGP 56696) 是一种用于治疗急性单纯性疟疾的抗疟药。

β-Hederin 是从 Hedera helix L.(Araliaceae) 分离得到的一种皂苷，具有抗利什曼虫活性。它对乳腺癌细胞有凋亡作用，有望成为乳腺癌化疗的候选药物。

Eupatoriopicrin shows anti-trypanosomal activity and cytotoxicity against Trypanosoma brucei rhodesiense. Eupatoriopicrin-induced DNA damage may play a role in the observed cytotoxicity, it shows a weak sensitizing capacity in guinea pigs.

Epimagnolin A 是一种糠醛木脂素，具有中等的抗疟原虫活性，IC50值为5.7 μg/mL。