Tyrosinase

Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents.

(-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.

Glabridin (KB-289522) 能够结合并激活PPARγ，EC50值为 6115 nM，是一种从Glycyrrhiza glabra 中分到的异黄烷类天然产物。它具有抗炎、抗菌、抗肾炎、抗氧化、抗肿瘤、抗糖尿病、抗骨质疏松、保护神经、保护心血管、清除自由基等作用。

Neorauflavane shows tyrosinase inhibition, it can inhibit tyrosinase monophenolase activity with an IC50 of 30 nM, it also can efficiently reduce melanin content in B16 melanoma cells with 12.95 uM of IC50.

Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells agai

Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.

XMD16-5 是TNK2抑制剂，对D163E 和R806Q 突变体的IC50值分别为16和77nM。

Monobenzone (Benoquin) 是皮肤脱色剂。它可引起色素脱失和活跃的人白癜风，对白癜风具有潜在的研究价值。

Ganodermanondiol是一种天然的黑色素(Melanogenesis)抑制剂，能够在B16F10细胞中抑制tyrosinase，TRP-1，TRP-2和MITF，影响MAPK和cAMP。Ganodermanondiol还具有抗炎作用和护肝作用，影响Nrf2依赖的HO-1和AMPK。

Arbutin (p-Arbutin) 是一种从熊果植物 Arctostaphylos uvaursi 中分离出的天然多酚，具有抗氧化，抗炎和抗肿瘤特性。它是一种脱色剂，也是一种黑色素细胞中酪氨酸酶的竞争性抑制剂，对单酚酶的 Kiapp 值为 1.42 mM；对二酚酶Kiapp 的值为 0.9 mM。

Polyphyllin C is a natural product

(R)-Trolox 是一种具有选择性的酪氨酸酶抑制剂，可用于食品、化妆品和医药产品中。

4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) 是一种药物中间体。它抑制单酚酶和二苯酚酶活性，IC50值分别为1.89 mM 和1.10 mM。 它有抗菌活性，抑制大肠杆菌的MIC 为250 μg/mL，MBC 为500 μg/mL。

Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.

3-O-Ethyl-L-ascorbic acid 是一种具有增白能力的化妆品酪氨酸酶 (tyrosinase) 抑制剂，是一种稳定的维生素 C 衍生物。它还具有抗氧化能力。

Taxiphyllin can inhibit tyrosinase activity in vitro significantly and is a potent tyrosinase inhibitor. Taxiphyllin displays mild antibacterial activity against Staphylococcus aureus.

Pseudostellarin G 为环八肽类天然产品，具有显著的抑制酪氨酸酶活性，可有效抑制黑色素生成。

Isobutylamido thiazolyl resorcinol 是一种有效的酪氨酸酶 (Tyrosinase) 抑制剂，专用于防止紫外线引起的色素沉着。

Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activation, MITF, and also by the subsequent downregulation of tyrosinase and TRP-1 production. Hag

Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of skin-whitening agents. Glyasperin C shows potent anti-vancomycin-resistant

Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein levels of tyrosinase, TRP-1, and TRP-2 in α-MSH-stimulated B16 melanoma cells.

Plodicitinib 是一种具有抗炎作用的 Janus 酪氨酸激酶 3/TEC 家族激酶（Janus tyrosine kinase 3/TEC family kinase）抑制剂。

Tyrosinase-IN-4 (compound 34) 是一种有效的酪氨酸酶抑制剂。酪氨酸酶是一种有前途的靶点，酪氨酸酶抑制剂可用作皮肤美白剂和食品防腐剂。 Tyrosinase-IN-4 在食品、化妆品、农业和医药等领域具有应用潜力[1]。

Mycosporine 2 glycine 是酪氨酸酶相关蛋白 1 (TYRP1) 的抑制剂，能有效结合 TYRP1，表现出良好的亲和力和稳定性。Mycosporine 2 glycine 对皮肤和眼睛可能造成轻度至中度刺激，并可用于防晒产品中以治疗色素沉着过度相关疾病。

Tyrosinase-IN-27（compound 6f）是一种酪氨酸酶（TYR）抑制剂，具有IC50为0.88 μM, 能有效静态猝灭TYR活性。该化合物通过与TYR结合，增加其微环境的疏水性，并通过减少α-螺旋的含量来改变酶的二级结构。在食品工业中，Tyrosinase-IN-27被用于抑制莲藕片的褐变现象。

Tyrosinase-IN-17 (Compound 5b), characterized as a lipophilic, skin-permeable, and non-cytotoxic tyrosinase inhibitor (pIC 50 = 4.99), is suited for research into melanin-related diseases, including melanoma and melanogenesis [1].

Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. Broussoflavonol F shows inhibitory activities on mushroom tyrosinase. Broussoflavonol F

HIV-1inhibitor-77 (compound 13) 作为一种有效的HIV-1抑制剂，具备针对多种病毒株的中和能力。它能够有效中和HIV-1CH58TF、HIV-1JRFL及HIV-1AD8三种病毒株，其IC50值分别为0.14 μM、8.28 μM和2.92 μM。

Tyrosinase-IN-39 (compound 5r) 作为一种酪氨酸酶 (tyrosinase) 的竞争性抑制剂，其IC50值达到 6.4 μM，主要被用于皮肤病研究领域。

2-Ketoglutaric acid-13C (Alpha-Ketoglutaric acid-13C) 是一种13C标记的2-Ketoglutaric acid，作为Krebs循环中ATP或GTP生成的关键中间体。它在氮同化过程中也充当主要的碳骨架。此外，2-Ketoglutaric acid 是酪氨酸酶(tyrosinase)的可逆抑制剂 (IC50=15 mM)。

Etarotene (Arotinoid ethyl sulphone) 是一种芦荟酸的乙基磺酰基衍生物，具有诱导分化和潜在的抗肿瘤活性。Etarotene 是一种胶原蛋白酶抑制剂，可用来研究银屑病。

Jineol (NSC-694081) 是一种来自蜈蚣 Scolopendra subspinipes 的喹啉生物碱。Jineol 在体外对人类肿瘤细胞系的生长具有细胞毒活性。

cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.

α-Arbutin (4-hydroxyphenyl-D-lucopyranoside) 是一种流行的、有效的皮肤增白剂，也是一种酪氨酸酶 (tyrosinase) 抑制剂。

Mulberroside F是一种发现于Morus alba L.的天然产物，能够抑制黑色素的生物合成和相关酪氨酸酶的活性，清除超氧化物和防止自氧化。

Beta-Tocopherol 对由 phorbol 12-myristate 13-acetate (PMA) 诱导的人红白血病细胞 (HEL) 粘附有影响。