Antibiotic

Zabofloxacin is a potent and seletive bacterial type II and IV topoisomerases inhibitor, and has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.

Mocimycin (Kirromycin) is an antibiotic originally isolated from Streptomyces and an inhibitor of protein biosynthesis. It inhibits isoleucine incorporation, polyphenylalanine synthesis, and growth of B. brevis. Kirromycin inhibits elongation factor Tu-dependent peptidyl transfer activity in E. coli.

15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activation of caspases independent of caspase-3[1].

Butylparaben (Butyl 4-hydroxybenzoate) 是一种标准化的化学过敏原，可增加组胺释放和细胞介导的免疫。

Methyl Paraben (Nipagin) 是一种标准化的过敏原，是从云南铁杉中分离出来对羟基苯甲酸的甲酯。它是一种抗菌剂、防腐剂、调味剂。它的生理作用是通过增加组胺释放和细胞调控免疫实现的。

N4Py是一种五齿配体，能够与铁、铜等金属离子形成稳定配位复合物，可模拟Bleomycin的金属结合结构域。其Fe²⁺-N4Py复合物可催化产生活性氧(ROS)，从而引发DNA氧化损伤及链断裂。基于其诱导氧化应激和DNA损伤的能力，N4Py体系常用于抗肿瘤相关机制研究。

Flumequine (R-802) 是一种喹诺酮类抗生素，对革兰氏阳性菌和革兰氏阴性菌均有效。它是拓扑异构酶 II 抑制剂， 抑制细胞分裂，IC50值为 15 μM (3.92 μg/mL)。

6-Diazo-5-oxo-L-nor-Leucine (DON) 属于谷氨酰胺拮抗剂，是一种不可逆谷氨酰胺分解抑制剂 (Ki=6 μM)，具有抗肿瘤（尤其胰腺癌）、抗菌及抗病毒活性。

DuP 105属于噁唑烷酮类化合物，是一种细菌蛋白合成抑制剂，具有口服活性和对革兰氏阳性菌的选择性抗菌作用。可用于研究由敏感革兰氏阳性菌如葡萄球菌和链球菌引起的感染，并在动物模型中显示保护效果。

Trovafloxacin mesylate属于氟喹诺酮类抗生素，是一种DNA促旋酶和拓扑异构酶IV的双重抑制剂，也是Pannexin 1通道的选择性抑制剂（IC50 = 4 μM）。具有口服活性、细胞渗透性且不抑制连接蛋白43或PANX2。用于抗菌研究。

Niclosamide 是一种经典的水杨酰胺类（salicylanilide）抗寄生虫药物，是一种多靶点、低毒性的广谱小分子调节剂，具有驱虫、抗肿瘤活性。Niclosamide 通过解偶联线粒体氧化磷酸化，破坏寄生虫能量代谢，导致 ATP 生成减少，从而杀灭寄生虫。Niclosamide 是 STAT3 抑制剂，在 HeLa 细胞中的 IC50 为 0.25 μM。

Berberine chloride (Natural Yellow 18) 是一种来自小檗科 Hydrastis canadensis L. 的生物碱，是常用的肠道抗菌药。Berberine chloride 具有抗炎、降糖、调脂、抗肿瘤、心血管保护等生物活性。Berberine chloride 可用于慢性病和肿瘤研究。

Staurosporine (AM-2282) 是一种蛋白激酶抑制剂，对 PKC、PKA、c-Fgr、Phosphorylase kinase 和 TAOK2 均有抑制活性 (IC50=6/15/2/3/3000 nM)，具有 ATP 竞争性和非选择性。Staurosporine 也可以诱导凋亡。

Bikaverin is a reddish pigment produced by different fungal species with antibiotic properties against certain protozoa and fungi. Bikaverin also has antitumoral activity against different cancer cell lines.

Corylin 是一种从补骨脂中分离的生物活性化合物，有抗生素或抗癌作用。

Helvolic acid, an antibiotic derived from Xylaria sp., exhibits effectiveness against Gram-positive bacteria.

Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2]. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA

Altromycin F is a new pluramycin-like antibiotic.

Saroaspidin A 是一种抗生素，提取自连翘Hypericum japonicum。

Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus. It is active against S. aureus when used at a concentration of 32 μg/ml. Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 μg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg. Gilvocarcin M intercalates into bacteriophage PM2 DNA. It is toxic to rats with an intravenous LD50 value of 450 mg/kg.

Lankacidinol A is a metabolite of macrolide antibiotic.

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

Justicidin C 是一种抗病毒木脂素，对水泡性口炎病毒展现了较强的抗病毒活性，同时在兔肺细胞(RL-33)中显示较低的细胞毒性。

Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimuriu

Espinomycin A2 是一种针对革兰氏阳性菌有效的十六元大环内酯类抗生素 (antibiotic)。

16-Methyloxazolomycin 是一种具有抗菌和抗藻类特性的抗生素，并对白血病 P388 细胞和人肺腺癌细胞有效。

Monamycin V 是一种酯肽抗生素，对革兰氏阳性菌表现出活性。

Malolactomycin C (compound 1) 属于大环内酯类抗生素,可从Streptomyces菌株 KP-3144中提取.这种化合物具有针对灰葡萄孢 (Botrytis cinerea) 的强效抑制作用,适用于防治包括灰霉病在内的多种植物病害.

Pluracidomycin A2 (PLM A2) 是一种碳青霉烯类抗生素，具备对革兰氏阳性菌和革兰氏阴性菌的活性。

Pluracidomycin C1 是一种碳青霉烯类抗生素，能够对抗革兰氏阳性菌和革兰氏阴性菌，同时具有抑制 β-内酰胺酶的功能。

Avidinorubicin is a novel anthracycline with platelet aggregation inhibitory activity.

Eurystatin B 是脯氨酰内肽酶 (PED) 的抑制剂，并在东莨菪碱诱导的大鼠遗忘过程中表现出保护作用。

Dynemicin O 是一种抗生素，展现出对革兰氏阳性菌的显著抑制作用。

Dermostatin B 是一种多烯类抗生素，显示出抗真菌活性，适用于真菌感染研究。

Megovalicin H 对枯草芽孢杆菌和大肠杆菌有效，同样对铜绿假单胞菌亦具活性。

Sakyomicin B 是一种苯醌类的抗生素，具有对革兰氏阳性菌和分枝杆菌的抗菌活性。