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化合物库
Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
Influenza Virus
Integrase
Parasite
Penicillin-binding protein (PBP)
RSV
Reverse Transcriptase
SARS-CoV
Virus Protease
ribosome
信号通路
微生物学
Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT214315455
Methyl protogracillin
TJS1748
54522-53-1
Methyl protogracillin 是来自 Dioscorea collettii var. hypoglauca 的天然产物,具有抗癌活性。
Antifection
HIT213885661
6-Deoxyjacareubin
TN3161
16265-56-8
6-Deoxyjacareubin 具有有效的抗氧化和抗真菌活性。 6-Deoxyjacareubin 抑制血小板活化因子 (PAF) 受体,IC50 为 29.0 microM,可用于天然 PAF 受体拮抗剂的研究。
Antifection
Antioxidant
PAFR
Platelet aggregation
Reactive Oxygen Species
HIT213884501
Nyasol
TN4683
96895-25-9
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly
Akt
Antibacterial
Antifection
Antifungal
ERK
IL Receptor
IκB/IKK
Leukotriene Receptor
NF-κB
NO Synthase
NOS
Parasite
HIT212665377
Corydalmine
TN1526
30413-84-4
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spore germination of all the fungi at 100 to 1500 ppm. l-Corydalmine also exhibits potent analgesic activity in preclinical models, it is under development as an oral analgesic agent.
Antifection
Antifungal
CXCR
Cytochromes P450
HIT213884952
22-Dehydroclerosterol
TN2809
26315-07-1
22-Dehydroclerosterol has antibacterial activity against against E. coli, S. aureus, and H. pylori.
Antifection
HIT214315760
Caesalmin E
TN3564
204185-91-1
Caesalmin E shows anti-Para3 virus activity.
Antifection
Influenza Virus
HIT213841538
Eritoran Tetrasodium
T27281
185954-98-7
Eritoran Tetrasodium, a TLR4 receptor antagonist, is used potentially for the treatment of type 2 diabetes.
Antifection
Others
TLR
HIT213884394
1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
TN2515
332371-82-1
(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one shows growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes, with the IC(50) value in the range of 1-3 microg/mL.
Antifection
Melanocortin Receptor
Others
HIT213884739
4-O-Methylsappanol
TN3063
104778-16-7
4-O-Methylsappanol shows activity against this fungus against Beauveria bassiana.
Antifection
Antifungal
HIT213885826
Isothymusin
TN4336
98755-25-0
Isothymusin( MIC= 200 microg/mL) exhibits inhibition activity against Mycobacterium tuberculosis. It ( IC50=7.7 microg/mL ) exhibits antioxidant activity against the radical scavenging ability of DPPH.
Antifection
Lipoxygenase
HIT213887004
Tetrahydroxysqualene
TN5134
1043629-23-7
Tetrahdroxysqualene shows antimycobacterial activity with an MIC of 10.0 microg/mL, while showing only modest cytotoxicity.
Antibacterial
Antifection
HIT212687431
Furomollugin
TN2417
61658-41-1
Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells.
Antibacterial
Antifection
HIT218850840
Cabenoside D
T75567
88901-40-0
Cabenoside D(化合物 8)是从苔藓根的甲醇提取物中分离的一种三萜苷,显示出对12-O-十四烷酰基激素-13-乙酸酯(TPA)诱导的小鼠炎症的抗炎活性,并能抑制TPA促使的Epstein-Barr病毒(EBV)早期抗原(EBV-EA)激活。
Antifection
Others
HIT213886544
Thalifoline
TN5139
21796-15-6
Thalifoline shows antifungal activity, with 100 ug against Fusarium oxysporum f. sp. lycopersici.
Antifection
Antifungal
HIT214314545
Kulactone
TN1838
22611-36-5
Kulactone has cytotoxic effects, with IC50 values of 5.6-21.2ug/mL, it inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line.
Antibacterial
Antifection
Antifungal
Parasite
HIT212650132
1-Docosanol
T0884
661-19-8
1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇,局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。
Antifection
HSV
HIT104682848
Fluconazole
T1388
86386-73-4
Fluconazole (UK-49858) 是一种对多种真菌具有活性的三唑类抗真菌剂,抑制 C. albicans 和 Candida kefyr 的 IC99为 0.20 μg/mL 至 0.39 μg/mL。
Antibacterial
Antibiotic
Antifection
Antifungal
HIT215290942
Tivicilovir
T67813
103024-93-7
Tivicilovir (AM188) 是一种乙型肝炎病毒抑制剂。tiviclovir 是一种鸟嘌呤相关的无环2'-脱氧鸟嘌呤类似物,具有抗疱疹病毒活性。
Antifection
HBV
HIT212650168
Cefmenoxime hydrochloride
T1190
75738-58-8
Cefmenoxime hydrochloride (Cefmenoxime hemihydrochloride) 是一种头孢类抗生素,可通过静脉内或肌肉内给药。 它对大多数常见的革兰氏阳性和革兰氏阴性微生物有活性,是一种肠杆菌科抑制剂,并且对 β-内酰胺酶的水解具有高度抗性。
Antibacterial
Antibiotic
Antifection
HIT214314559
Mogroside VI
TN1938
189307-15-1
Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga
Antifection
HIT212665683
(+)-Medioresinol
TN1919
40957-99-1
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α²-secretase, it is a potentially valuable antiamyloidogenic agent for the prevent
Akt
Antibacterial
Antifection
Antifungal
Apoptosis
Beta Amyloid
Interleukin
MMP
mTOR
PGC-1α
PI3K
PPAR
Pyroptosis
Reactive Oxygen Species
ROS
HIT212038915
Fumitremorgin B
TN4084
12626-17-4
Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic
Antifection
Antifungal
Endogenous Metabolite
HIT212665785
Pendulone
TN2047
69359-09-7
Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.
Antibacterial
Antifection
Parasite
HIT212083331
Penciclovir
T1643
39809-25-1
Penciclovir (BRL 39123) 是一种疱疹病毒核苷类似物 DNA 聚合酶抑制剂。它作用于HSV1 和 2,IC50分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。
Antifection
HCV Protease
HSV
HIT213885289
1,4,7-Eudesmanetriol
TN2495
145400-02-8
1α,4β,7β-Eudesmanetriol and 1β,4β,7β-Eudesmanetriol can inhibit growth of Pseudomonas stutzeri with a MIC value of 117 uM, they also show remarkable activities against acetylcholinesterase enzyme with IC50 values ranging between 25 and 26 uM.
Antifection
HIT213886590
Sageone
TN4932
142546-15-4
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity.
Akt
Antifection
Apoptosis
Caspase
PARP
HIT213885074
beta-Amyrone
TN3500
638-97-1
beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性,EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。
AChR
Antifection
Antifungal
COX
PPAR
HIT212649972
Voriconazole
T0120
137234-62-9
Voriconazole (UK-109496) 是一种三唑类抗真菌剂,可抑制真菌麦角甾醇的生物合成。它特异性抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用
Antibacterial
Antifection
Antifungal
HIT213885291
Macrocarpal D
TN4476
142647-71-0
Macrocarpal D is a HIV-RTase inhibitor. It has antibacterial activity.
Antibacterial
Antifection
HIT218697993
CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)
TP1267
254110-79-7
HLA-A*0301-restricted epitope from Epstein-Barr Virus , EBV BRLF-1 (148-156).
Antifection
HIT213884941
Clauszoline M
TN3674
187110-72-1
Clauszoline M shows a significant anti-tuberculosis activity.
Antifection
HIT213885287
Eucalyptin
TN4023
3122-88-1
Eucalyptin has antioxidant and antimicrobial properties, it exhibits potent antimicrobial activities against seven micro-organisms with minimum inhibitory concentrations (MIC) ranging from 1.0 to 31 mg/L. Eucalyptin A exhibits potent inhibition on HGF/c-M
Antifection
HIT213885388
Stigmastane-3,5,6-triol
TN5067
20835-91-0
Stigmastane-3,5,6-triol and derivatives could be used for preparing antiviral medicine.
Antifection
HIT213885019
Cryptofolione
TN3721
160098-78-2
Z-Cryptofolione and Cryptomoscatone D2 as highly efficacious inhibitors of the G(2) checkpoint, G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis. Cryptofolione shows moderate cytotoxicity in both macrophages and T. cruzi amastigotes, it also displays a mild inhibitory effect on the promastigote form of Leishmania spp.
Antifection
HIT212665586
Isorhamnetin 3-glucoside-7-rhamnoside
TN1792
17331-71-4
An anti-oxidative composition containing isorhamnetin-3-glucoside-7-rhamnoside (IGR)isolated from Hippophae rhamnoides L. is provided to ensure antioxidative, antibacterial, and anti-cancer effect.
Antifection
HIT212525009
3,4,5-Trimethoxycinnamyl alcohol
TN2866
30273-62-2
3,4,5-Trimethoxycinnamyl alcohol shows significant antimicrobial and cytotoxic activities.
Antifection
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