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Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
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Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT212665954
Thalrugosaminine
TN2271
22226-73-9
Thalrugosaminine shows promising antibacterial activity with MIC values of 64-128ug/ml and Staphylococcus species is the most sensitive strains. Thalrugosaminine possesses hypotensive activity in rabbits and is active against Mycobacterium smegmatis.
Antibacterial
Antifection
HIT214315920
Ganoderic acid ζ
TN4108
294674-09-2
The binding affinities of ganoderic acid DM andGanoderic acid ζ (ÎGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.
Antifection
HIT219200887
20-Hydroxylucidenic acid E2
TN8399
852567-75-0
20-Hydroxylucidenic acid E2 是一种在 Ganoderma ludicum 中发现的三萜类化合物,对 TPA 诱导的炎症具有显著的抑制作用。此外,20-Hydroxylucidenic acid E2 能抑制 TPA 诱导的 EBV 早期抗原表达,IC50 为 290 mol ratio/32 pmol TPA(即当此化合物的摩尔浓度为 TPA (32 pmol) 的 290 倍时,能抑制 50% 的 EBV 早期抗原表达)。20-Hydroxylucidenic acid E2 可用于抗炎和抗癌研究。
Antifection
EBV
HIT214315803
Cynatratoside A
TN3747
97399-96-7
Cynatratoside A and Cynanversicoside C are therefore potential candidate drugs for use against Ichthyophthirius multifiliis.
Antifection
HIT213884270
Platyphyllenone
TN4808
56973-65-0
Platyphyllenone 存在于 Alnus nepalensis 中并显示出抗丝虫活性。
Antifection
HIT101420085
Nigracin
TN4656
18463-25-7
Nigracin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4656,CAS号为 18463-25-7。
Antifection
HIT213886850
Dehydrocrebanine
TN3799
77784-22-6
Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. It also shows potent antimalarial activity with an IC50 value of 70 ng/ml.
Antifection
HIT218850840
Cabenoside D
T75567
88901-40-0
Cabenoside D(化合物 8)是从苔藓根的甲醇提取物中分离的一种三萜苷,显示出对12-O-十四烷酰基激素-13-乙酸酯(TPA)诱导的小鼠炎症的抗炎活性,并能抑制TPA促使的Epstein-Barr病毒(EBV)早期抗原(EBV-EA)激活。
Antifection
Others
HIT214314559
Mogroside VI
TN1938
189307-15-1
Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga
Antifection
HIT212665233
8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone
TN1344
1000415-56-4
8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone may have antifungal activity against phytopathogenic and human pathogenic fungi.
Antifection
HIT213886590
Sageone
TN4932
142546-15-4
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity.
Akt
Antifection
Apoptosis
Caspase
PARP
HIT213884501
Nyasol
TN4683
96895-25-9
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly
Akt
Antibacterial
Antifection
Antifungal
ERK
IL Receptor
IκB/IKK
Leukotriene Receptor
NF-κB
NO Synthase
NOS
Parasite
HIT212665287
Azadirachtin
TN1417
11141-17-6
Azadirachtin 是一种有前途的植物源杀虫剂,能够诱导昆虫 Sf9、SL-1 和 BTI-Tn-5B1-4 细胞凋亡。它广泛用于害虫防治。
Antifection
Apoptosis
Bcl-2 Family
Caspase
NF-κB
Parasite
HIT213884292
Glyasperin C
TN4148
142474-53-1
Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of skin-whitening agents. Glyasperin C shows potent anti-vancomycin-resistant
Antifection
Tyrosinase
HIT214314467
7-Ethoxyrosmanol
TN1329
111200-01-2
7-Ethoxyrosmanol has cytotoxic and antimicrobial activities.
Antifection
HIT213886544
Thalifoline
TN5139
21796-15-6
Thalifoline shows antifungal activity, with 100 ug against Fusarium oxysporum f. sp. lycopersici.
Antifection
Antifungal
HIT212665372
Colutehydroquinone
TN1521
181311-16-0
Colutehydroquinone 是一种从Colutea arborescens 的根皮中提取的异黄酮,具有抗真菌活性。
Antifection
Antifungal
HIT213886014
Mulberrofuran H
TN4588
89199-99-5
Mulberrofuran H exhibits potent antifungal activity against phytopathogenic fungi Colletotrichum orbiculare, Phytophthora capsici, Corynespora cassiicola and Fusarium oxysporum.
Antifection
Dopamine Receptor
HIT212665785
Pendulone
TN2047
69359-09-7
Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.
Antibacterial
Antifection
Parasite
HIT104682848
Fluconazole
T1388
86386-73-4
Fluconazole(UK-49858)属于三唑类抗真菌剂,是一种CYP51抑制剂(对白色念珠菌IC99=0.20–0.39 μg/mL),具有广谱抗真菌活性、良好口服吸收和细胞渗透性,用于多种侵袭性真菌感染研究。
Antibacterial
Antibiotic
Antifection
Antifungal
HIT214314545
Kulactone
TN1838
22611-36-5
Kulactone has cytotoxic effects, with IC50 values of 5.6-21.2ug/mL, it inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line.
Antibacterial
Antifection
Antifungal
Parasite
HIT107175067
Thunberginol C
TMA0955
147517-06-4
Thunberginol C exhibits antimicrobial activity against oral bacteria. It shows antiallergic activity in the in vitro bioassay using the Schults-Dale reaction in sensitized guinea pig bronchial muscle.
Antibacterial
Antifection
HIT214315487
1-Methoxyphaseollidin
TMA2418
65428-13-9
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Methoxyphaseollidin may show moderate cytotoxic activity against KB and L1210 cells. 1-Methoxyphaseollidin also shows inhibition of lysoPAF acetyltransferase activity.
Antibacterial
Antifection
Endogenous Metabolite
PAFR
HIT214312026
α-Cembrenediol
T124625
57605-80-8
α-Cembrenediol 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124625。
Antifection
Others
HIT212665683
(+)-Medioresinol
TN1919
40957-99-1
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α²-secretase, it is a potentially valuable antiamyloidogenic agent for the prevent
Akt
Antibacterial
Antifection
Antifungal
Apoptosis
Beta Amyloid
Interleukin
MMP
mTOR
PGC-1α
PI3K
PPAR
Pyroptosis
Reactive Oxygen Species
ROS
HIT212021163
Valpromide
T0355
2430-27-5
Valpromide (Dipropylacetamide) 是丙戊酸的羧酰胺衍生物,用于治疗癫痫和一些情感障碍。
Antifection
Epoxide Hydrolase
HSV
HIT214315455
Methyl protogracillin
TJS1748
54522-53-1
Methyl protogracillin 是来自 Dioscorea collettii var. hypoglauca 的天然产物,具有抗癌活性。
Antifection
HIT211998370
Chlorhexidine diacetate
T1000L
56-95-1
Chlorhexidine diacetate (Bactigras) 是一种双胍类杀菌剂,能快速消灭革兰氏阳性菌和革兰氏阴性菌。它也用作漱口水以防止口腔菌斑。
Antibacterial
Antibiotic
Antifection
Apoptosis
Necroptosis
HIT102453534
Ganciclovir
T0688
82410-32-0
Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物,对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
Antibiotic
Antifection
HSV
Nucleoside Antimetabolite/Analog
Virus Protease
HIT219561241
VK-1727
T78598
VK-1727 是一种选择性的小分子 EBNA1 抑制剂,可降低 EBNA1 的 DNA 结合活性,同时限制 EBV 阳性细胞的增殖和代谢活性,而不影响 EBV 阴性细胞的存活。VK-1727 主要应用于多发性硬化症相关研究,作为工具化合物用于探索 EBNA1 介导的疾病相关机制。
Antifection
DNA
HIT213840511
Desciclovir
T22304
84408-37-7
Desciclovir (DCV) 是抗疱疹药物阿昔洛韦的前药,口服有活性,在体内被黄嘌呤氧化酶转化成为阿昔洛韦。
Antibacterial
Antibiotic
Antifection
Apoptosis
HSV
Others
HIT212083316
Terconazole
T2213
67915-31-5
Terconazole (Terazol 7) 是一种广谱抗真菌药物,用于研究阴道酵母菌感染。
Antifection
Antifungal
HIT102905347
Econazole
T0444
27220-47-9
Econazole ((±)-Econazol) 是一种咪唑衍生物,是一种抗真菌剂。
Antibacterial
Antibiotic
Antifection
Antifungal
Calcium Channel
Cytochromes P450
HIT213887188
Altechromone A
TN3400
38412-47-4
Altechromone A has antimicrobial activity, it is active against Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens and Candida albicans with the MICs of 3.9, 3.9, 1.8, and 3.9 ug/ml, respectively.
Antifection
NF-κB
NOD-like Receptor (NLR)
HIT220772288
14-O-Acetylindolactam V
TN11318
91403-61-1
14-O-Acetylindolactam V 能够诱导早期 Epstein-Barr 病毒抗原的表达。
Antifection
HIT212665338
Cerebroside B
TN1481
88642-46-0
Cerebroside B1b has antiulcerogenic activity.
Antifection
Antifungal
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