RAAS

YS-49 是一种PI3K/Akt(RhoA 的下游靶标) 的激活剂，可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。它是异喹啉化合物生物碱，因能激活心脏β-adrenoceptors 而具有强烈的正性肌力作用。它能通过诱导血红素加氧酶来抑制血管紧张素 II 刺激 VSMC 细胞的增殖。

FK-739 is an angiotensin type 1 receptor antagonist. FK 739 inhibits the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane (IC50 = 8.6 nM) without displacing the specific binding of [125I]-angiotensin II to bovine cerebel

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.

Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的，不含巯基的血管紧张素转化酶抑制剂，可治疗高血压和充血性心力衰竭。

BIBS 39是新型的非肽类血管紧张素II（AII）受体拮抗剂。

Fimasartan (BR-A-657) 是血管紧张素受体 AT1 非肽类拮抗剂，用于研究高血压和心力衰竭。

Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.

Bopindolol is a non-selective β-adrenergic receptor antagonist. In vivo, bopindolol decreases heart rate and blood pressure and attenuates ischemia-induced myocardial acidosis in dogs. Formulations containing bopindolol have been used to treat essential and renovascular hypertension.

Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium. NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.

Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。

Quinapril hydrochloride (PD-109452-2) 是一种血管紧张素转化酶(ACE) 抑制剂的原药。

ZD 7155 hydrochloride 是血管紧张素II 受体1型 (AT1 receptor) 拮抗剂。

Zabicipril 是一种新型可口服的血管紧张转换酶抑制剂，是一种前药，在体内脱酯后具有抗高血压活性。

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers.

Lisinopril dihydrate （MK-521) 是一种血管紧张素转化酶抑制剂。Lisinopri dihydrate 能够作用于高血压，充血性心力衰竭和心脏病等。

Dehydro Olmesartan, deriving from Olmesartan, acts as an angiotensin II receptor (AT1R) antagonist and exhibits potential for the study of high blood pressure [1][2].

PD 132002 is a renin inhibitor.

Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. It selectively and competitively blocks the binding of angiotensin II to the angiotensin I receptor.

SSAA09E2 是一种新型的SARS-CoV 复制抑制剂，通过阻断SARS-S 与SARS-CoV 受体血管紧张素转换酶-2 的早期相互作用发挥作用。

Leucylarginylproline 是一种血管紧张素转换酶抑制剂，IC50=为0.27μM。

Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) 是肾素-血管紧张素系统中的内源性七肽。Angiotensin 1-7在心肌细胞中具有抗炎和抗纤维化活性，因此具有心脏保护作用。它能抑制血管紧张素转换酶和释放一氧化氮，是激肽诱导的血管舒张的局部协同调节剂。它阻断 Ang II 诱导的平滑肌细胞增殖和肥大，并显示对内皮的抗血管生成和生长抑制作用。它显示出抗炎活性。

Olodanrigan (EMA401) 是具有口服活性、高选择性及外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。它的缓解疼痛的机制可能是：抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活，进而阻碍 DRG 神经元的过度兴奋性及 DRG 神经元的萌发。它可用于研究神经性疼痛。

Angiotensin (1-7) acetate (Ang-(1-7) acetate) 是存在于血管紧张素中的一段氨基酸序列，具有抗纤维化和心脏保护作用，抑制纯化的犬血管紧张素转换酶 (ACE) 活性。Angiotensin (1-7) acetate 抑制肿瘤细胞的生长并减少几种类型癌症的局部炎症和血管生成，阻断血管紧张素 Ⅱ 诱导的平滑肌细胞增殖和肥大，可用于研究动脉粥样硬化和新型冠状病毒感染。

JHU-083 是一种可口服、可穿过血脑屏障且具有选择性的谷氨酰胺酶 (glutaminase) 拮抗剂，可改善 APOE4 小鼠的认知能力，使异常的海马谷氨酰胺酶活性正常化。

AT2R-IN-1 (A-174)是一种AT2R抑制剂，适用于神经性疼痛的研究。

Emd 55068 is a synthetic antagonist of renin.

ES 6864 is an orally active inhibitor of renin.

Embusartan (BAY 10-6734) is a potent, orally active angiotensin II receptor antagonist used as an antihypertensive agent.

CI 992 is a novel potent inhibitor of primate renin.

Locicortolone is a synthetic glucocorticoid corticosteroid which was never marketed.

Emd 52297 is an inhibitor of renin.

Mitolactol is an alkylating antineoplastic toxic to bone marrow; utilized in breast cancer, also in combination with other drugs. Mitolactol is able to cross bloodbrain barrier, consequently could control certain brain tumors.

A 65317 is a selective renin inhibitor that causes a blockade of the renin-angiotensin system.

5-O-beta-D-Glucopyranosylmyricanol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T123967。

L 681176 is an inhibitor of the angiotensin-converting enzyme.

(+)-Chloroquine是一种影响血管紧张素转换酶2（ACE-2）末端糖基化的氨基喹啉药物，其作用表现在体外。