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Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
Influenza Virus
Integrase
Parasite
Penicillin-binding protein (PBP)
RSV
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信号通路
微生物学
Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT212665128
2,3,8-Tri-O-methylellagic acid
TN1203
1617-49-8
2,3,8-tri-O-Methyl ellagic acid has antimicrobial activity agaist Vibro cholera, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Escherichia coli.
Antifection
HIT101565811
5,6,7-Trimethoxycoumarin
TN3080
55085-47-7
5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp larvae. 5,6,7-Trimethoxycoumarin can improve gastroprotective effects, and it has low toxicity
Antifection
Cytochromes P450
HIT212665811
Pinocembrin chalcone
TN2078
4197-97-1
Pinocembrin chalcone 是一种具有抗诱变作用的酪氨酸酶抑制剂。 Pinocembrin 查尔酮可用于预防胃溃疡的研究。
AMPK
Antibacterial
Antifection
Calcium Channel
Tyrosinase
HIT213885566
(+/-)-Sigmoidin A
TN5020
176046-04-1
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
Antifection
Lipoxygenase
HIT212665985
Wulignan A1
TN2311
117047-76-4
Wulignan A1 是一种从华中五味子 (Schisandra henryi) 茎部分离得到的天然二苯并环辛二烯型木脂素化合物,具有抗流感病毒与抗肿瘤双重生物活性。Wulignan A1 对甲型流感病毒 H1N1 及达菲耐药株 H1N1-TR均表现出抑制活性。
Influenza Virus
HIT213884722
2-Acetoxy-3-deacetoxycaesaldekarin E
TN2747
18326-06-2
2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
Antifection
HIT212665402
Dehydroglaucine
TN1561
22212-26-6
Dehydroglaucine is an acetylcholinesterase inhibitor, it shows antimicrobial activity against Staphylococcus aureus, Mycobacterium smegmatis, Candida albicans, and Aspergillus niger.
Antibacterial
Antifection
HIT213885382
Canthin-6-one N-oxide
TN3584
60755-87-5
Canthin-6-one N-oxide has broad spectrum antifungal, leishmanicidal and trypanocidal activities.
Antifection
Parasite
HIT100069072
Carabrone
TN1114
1748-81-8
Carabrone 是分离自Carpesium abrotanoides 果实的一种倍半萜,表现出显著抗肿瘤活性和抗菌活性,如灰霉病菌Botrytis cinerea,炭疽病菌Colletotrichum lagenarium 和禾白粉菌Erysiphe graminis。
Antibacterial
Antifection
HIT104971689
Ferruginol
TN1642
514-62-5
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells.
Antifection
Apoptosis
Bcl-2 Family
Caspase
HSV
PARP
HIT214315858
Effusanin A
TN3920
30220-43-0
Effusanin A 是一种存在于Isodon rugosus 之中的天然产物。 它具有 DNA 损伤和抗菌作用。
Antibacterial
Antifection
Raf
HIT214314552
Yadanzioside L
TN2321
99132-97-5
Yadanzioside L shows strong antiviral activity.
Antifection
TMV
HIT214315766
Camaric acid
TN3573
146450-83-1
Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity. Camar
Antibacterial
Antifection
HIT213884775
Lyoniside
TN4470
34425-25-7
Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates. The
Antifection
Antifungal
HIT212665516
Glycyrin
TN1703
66056-18-6
Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
Antibacterial
Antifection
HCV Protease
PPAR
HIT213884307
Khellactone
TN4387
24144-61-4
Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.
Antifection
HIT213885876
Vestitol
TN5228
35878-41-2
Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from 25-50 to 50-100 ug/mL and MBCs ranging from 25-50 to 50-100 ug/mL.Vestitol exerts a limited inhibitory effect on S. hermonthica germination, it can significantly inhibit seedling growth, it also contributes, at least in part, to the host's defence mechanism and acts as a chemical barrier against the intrusion of the parasite.
Antifection
HIT213884656
11,13-Dihydroivalin
TN2579
150150-61-1
11,13-Dihydroivalin是一种天然产物,属于菊科艾纳香属,其产品编号为 TN2579,CAS号为 150150-61-1。11,13-Dihydroivalin可用作对照参考。
Antifection
HIT213840686
Trichorabdal A
TN5173
85329-59-5
Trichorabdal A 是一种二萜化合物,分离自 Rabdosia trichocarpa,抗肿瘤作用强大。
Antibacterial
Antifection
HIT213886290
Dehydroabietinol
TN3790
3772-55-2
Dehydroabietinol (Pomiferin A) 在体外抑制红细胞中的氯喹敏感及氯喹抵抗型疟原虫,IC50为26-27 μM.
Antifection
Syk
HIT214315822
Dehydrobruceine A
TN3797
73435-47-9
Dehydrobruceine A shows strong antitrypanosomal activities with IC(50) values in the range of 2.9-17.8nM.
Antifection
Parasite
HIT214316020
Macrocarpal I
TN4479
179388-54-6
Macrocarpal I has anti-glucosyltransferase, and anti-bacterial activities.
Antifection
Antifungal
HIT213885091
Isopimaric acid
TN4319
5835-26-7
Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interacti
Antifection
Potassium Channel
HIT213884420
Agrimonolide 6-O-glucoside
TN3363
126223-29-8
Agrimonolide-6-O-glucopyranoside has antimicrobial activity.
Antifection
HIT214316278
Zeorin
TN5279
22570-53-2
Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows potent inhibitory effect by 40% decrease of histamine release.
Antibacterial
Antifection
Antifungal
ATPase
Calcium Channel
Histamine Receptor
Others
HIT212665340
Cheilanthifoline
TN1484
483-44-3
Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts.
Antifection
NF-κB
Parasite
HIT213884500
Kaempferol-7,4'-dimethyl ether
TN2898
15486-33-6
Kaempferol-7,4'-dimethyl ether 是从 Zingiber phillipseae 的根茎中分离得到的,对金黄色葡萄球菌和大肠杆菌具有抗氧化活性,MIC 分别为 200 和 225 μg/ml。
Antifection
Antioxidant
Phosphatase
HIT212687405
9,17-Octadecadiene-12,14-diyne-1,11,16-triol
TN2392
211238-60-7
9,17-Octadecadiene-12,14-diyne-1,11,16-triol shows antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata at low concentratio
Antibacterial
Antifection
Antifungal
HIT214316102
Physalin H
TN4778
70241-09-7
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both
Antifection
Autophagy
Endogenous Metabolite
gp120/CD4
Hedgehog/Smoothened
HIT213886036
Minumicrolin
TN4570
88546-96-7
Minumicrolin is a plant growth inhibitor against the 2nd leaf sheath elongation of rice seedlings. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100, it might be valuable anti-tumor-promoting agents. Minumicrolin shows mild butyrylcholinesterase inhibition activity.
Antifection
HSV
Others
HIT213884257
Esculentoside B
TN4014
60820-94-2
Phytolaccoside B(Esculentoside B) is an antifungal monodesmoside triterpenoid glycoside, it has potent inhibitory activity against agrobacterial plant transformation.
Antifection
Antifungal
Cholinesterase (ChE)
JNK
NF-κB
HIT212876190
(+/-)-Vestitol
TN5227
56701-24-7
(+/-)-Vestitol 是一种天然羟基异黄酮(hydroxyisoflavan),存在于巴西红蜂胶、甘草根、三叶草等植物。(+/-)-Vestitol 具有抗炎、抗氧化、抗菌、抗寄生虫等生物活性。
Antifection
HIT212715972
Eprociclovir
T31659
145512-85-2
Eprociclovir (A-5021) 是一种新型阿昔洛韦类似物,是 EHV1 复制的强效抑制剂,可能用于治疗和/或预防该病毒感染。Eprociclovir 对大多数人类疱疹病毒都有很强的抗疱疹活性。
Antifection
DNA/RNA Synthesis
HIT213886253
1-Acetyl-β-carboline
TN2524
50892-83-6
1-Acetyl-β-carboline 是一种来源于 Streptomyces kasugaensis 的生物活性代谢物,具有抗菌活性,可增强酪氨酸酶活性、降低 ERK 磷酸化并增加黑色素生成。1-Acetyl-β-carboline 对耐甲氧西林金黄色葡萄球菌表现出抗菌作用,其最低抑菌浓度为 128–256 μg/mL,支持其在抗微生物及色素生成相关生化研究中的应用。
Antifection
Drug Metabolite
HIT106925444
Chlorhexidine dihydrochloride
T1147
3697-42-5
Chlorhexidine dihydrochloride (NSC-185) 是一种消毒剂和局部抗感染剂,也用作漱口水以防止口腔菌斑。
Antibacterial
Antibiotic
Antifection
Apoptosis
Cell wall
Necroptosis
HIT217591257
GR-95168
T67800
95463-56-2
GR-95168 ((+)-C-BVDU) 是一种抗病毒化合物,可用于研究1型和2型单纯疱疹病毒感染。
Antifection
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