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供应商货号
CAS号
HIT ID
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化合物库
Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
Influenza Virus
Integrase
Parasite
Penicillin-binding protein (PBP)
RSV
Reverse Transcriptase
SARS-CoV
Virus Protease
ribosome
信号通路
微生物学
Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT213885597
Coronarin B
TN3707
119188-38-4
Coronarin B has cytotoxic activity, it also has modest antiplasmodial activity.
Antifection
HIT212665373
Combretol
TN1522
5084-19-5
Combretol has leishmanicidal activity, it showed moderate activity (growth inhibition 87.3 and 73.0 %, respectively, at 50 μM) against a multidrug-resistant L. tropica line. Combretol also shows weakly active cytotoxic activity.
Antifection
HIT213885273
Erysenegalensein E
TN3990
154992-17-3
Erysenegalensein E是一种天然产物,属于豆科刺桐属,其产品编号为 TN3990,CAS号为 154992-17-3。Erysenegalensein E可用作对照参考。
Antifection
HIT213884311
Manassantin B
TN4490
88497-88-5
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.
Antifection
Bcl-2 Family
ERK
JNK
NF-κB
p38 MAPK
STAT
TNF
HIT213887316
FD-838
TN4053
110341-78-1
FD-838 shows good antileishmanial and moderate anticancer activities, it can moderately inhibit the growth of cultured P388 and HL-60 cell lines. FD-838 has anti-fungal activity, it can significantly inhibit the growth of two plant fungal pathogens Botryt
Antifection
HIT103412988
16-Oxocleroda-3,13E-dien-15-oic acid
TN2650
117620-72-1
16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity.
Antifection
HIT214315792
Coronarin D
TN3708
119188-37-3
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i
Antifection
Bcl-2 Family
Caspase
c-Myc
COX
NF-κB
TNF
HIT213886985
6,7-Dihydroneridienone A
TN3145
72959-46-7
6,7-Dihydroneridienone A exhibits notable leishmanicidal activity.
Antifection
HIT213885569
Dihydrolicoisoflavone
TN3852
164163-92-2
Dihydrolicoisoflavone A possesses weaker anti-H. pylori activity, it may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals.
Antifection
HIT214315754
Cabraleadiol
TN3557
67253-01-4
Cabraleadiol displays antimycobacterial activity against Mycobacterium tuberculosis, it also is weakly cytotoxic to a breast cancer (BC) cell line. Cabraleadiol inhibits photosystem II (PS II) and induces the appearance of small G band which is related wi
Antifection
ATPase
HIT214316079
Norcaesalpinin E
TN4666
854038-96-3
Norcaesalpinin E shows antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro, with an IC50 value of 0.090 microM.
Antifection
HIT213885782
Pterodondiol
TN4851
60132-35-6
Pterodondiol has moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei and Bacillus circulans.
Antifection
HIT213887312
Tryprostatin A
TN5190
171864-80-5
Tryprostatin A is an inhibitor of breast cancer resistance protein and, along with tryprostatin B, is an indole alkaloid-based fungal product that inhibits the mammalian cell cycle at the G2/M phase.
Antifection
Topoisomerase
HIT105586241
Alpinumisoflavone
TN3397
34086-50-5
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is endowed with estrogenic properties accounting, at least in part, for E. lysistemon effects. Alp
Antifection
ERK
LDL
MAPK
MEK
NF-κB
HIT213885017
ent-17-Hydroxykauran-3-one
TN3943
960589-81-5
ent-17-Hydroxy-16α-kauran-3-one shows weak antimicrobial activity when tested against Staphylococcusaureus.
Antifection
HIT213887386
Benzyl ferulate
TN3495
132335-97-8
Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE-30 oesophageal squamous cancer, and NCI-N87 gastric carcinoma).
Antifection
TNF
HIT213887299
Vibralactone B
TN5229
1093230-95-5
Vibralactone B shows antibacterial activity, it can inhibit significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 ug/mL, respectively.
Antifection
HIT213886585
Taxoquinone
TN5119
21764-41-0
Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens. It (100 ug/disc) displays potential anticandidal effect against Candia albica
Antifection
Tyrosinase
HIT213885518
2-Methoxyanofinic acid
TN2772
179457-70-6
2-Methoxyanofinic acid is active against the plant pathogenic fungus Cladosporium cucumerinum.
Antifection
HIT213884203
15-Hydroxydehydroabietic acid
TMA0164
54113-95-0
15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.
Antifection
Cytochromes P450
Others
HIT214314438
Isocolumbin
TN1133
471-54-5
Isocolumbin has anti-inflammatory, and antimicrobial activities.
Antifection
Endogenous Metabolite
HIT106006139
Eupatoriochromene
TN4040
19013-03-7
Eupatoriochromene retard seed germination , reduced radicle and hypocotyl growth of weed and crop plant seedlings and increased adventitious root formation of mung bean cuttings. Eupatoriochromene has insecticidal activity, it exhibits toxicity againstCul
Antifection
Xanthine Oxidase
HIT214315709
Arteannuin M
TN3452
207446-90-0
Arteannuin M is one of the main component of Arteannuin, which shows antimalarial activity. Arteannuin can degrade the level of TNF-α in rats with ostarthritis and inhibit the inflammation effectively.
Antifection
Parasite
TNF
HIT214316018
Macrocarpal C
TN4475
142628-53-3
Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associated with increases of membrane permea
Antifection
Antifungal
ROS
HIT213885580
Monomethyl kolavate
TN4578
24513-41-5
Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.
Antifection
Parasite
HIT219251338
Porritoxin
TN8984
143114-82-3
Porritoxin (compound1) 是 Alternaria porri 的一种代谢产物。此化合物能够抑制12-O-tetradecanoylphorbol-13-acetate (TPA) 诱导的EB病毒早期抗原 (EBV-EA) 的活化。
Antifection
EBV
HIT213886054
Musellactone
TN4596
907583-51-1
Musellactone shows different effects against five bacteria strains.
Antibacterial
Antibiotic
Antifection
HIT213887002
Sativan
TN4953
71831-00-0
Sativan possesses a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi, it exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with the MIC value of 50 ug/mL.
Antibacterial
Antifection
Antifungal
HIT212665172
3-Feruloylquinic acid
TN1262
1899-29-2
3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
Antifection
COX
Interleukin
NF-κB
NO Synthase
Proteasome
HIT212715972
Eprociclovir
T31659
145512-85-2
Eprociclovir (A-5021) 是一种新型阿昔洛韦类似物,是 EHV1 复制的强效抑制剂,可能用于治疗和/或预防该病毒感染。Eprociclovir 对大多数人类疱疹病毒都有很强的抗疱疹活性。
Antifection
DNA/RNA Synthesis
HIT100257409
(E)-Ferulic acid methyl ester
T3S0006
22329-76-6
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) 具有较强 DPPH 和 ABTS+自由基清除特性。
Antifection
COX
IL Receptor
JNK
NO Synthase
p38 MAPK
TNF
HIT212665455
Euparin
TN1632
532-48-9
Euparin exhibits a moderate antioxidant activity, it also exhibits antifungal activity against Trichophyton mentagrophytes. Euparin has antiviral activity, it exerts its effect during the early events of the replication cycle, from the virus adsorption to
Antifection
Reactive Oxygen Species
ROS
HIT213885225
Echimidine
TN3913
520-68-3
Echimidine((+)-Echimidine,蓝蓟定)是一种天然的吡咯里西啶(pyrrolizidine)生物碱和直接的AChE抑制剂,还与毒蕈碱受体(Muscarinic receptors)和5-HT2具有结合活性,可用于研究阿尔茨海默病。
Antifection
Others
HIT213886034
Murraol
TN4594
109741-38-0
Murraol shows the significant proliferative activities on osteoblast-like UMR106 cells lines at the concentration of 1 × 10-10 mol/L. It and auraptenol show 63 ug/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372.
Antifection
COX
Lipoxygenase
HIT100243311
Arborinine
TN3438
5489-57-6
Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0.7 ug/ml. Arborinine shows antifeedant activity against Spodoptera frugiperda. Arborinin shows
Antifection
HCV Protease
Histone Demethylase
HIT214315963
Isochamaejasmine
TN4271
93859-63-3
Isochamaejasmine 分离自 S. chamaejasme L. 中分离出来,可抑制 NF-κB 活化。 Isochamaejasmine 通过抑制 Bcl-2 家族蛋白的活性诱导白血病细胞凋亡,可用于抗癌研究。
Antifection
Apoptosis
Bcl-2 Family
Caspase
DNA/RNA Synthesis
ERK
NF-κB
p38 MAPK
Parasite
PARP
PKC
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