Oxytocin Receptor

L-366,509 is an antagonist of oxytocin.

L-372662 is bioactive chemical.

L 364918 is an oxytocin antagonist.

5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when used at a concentration of 10 μg/ml, an effect that can be blocked by the progesterone receptor antagonist RU486 but not the GABAAreceptor antagonist picrotoxin .1It is a negative modulator of homooligomeric Ρ1 subunit-containing GABAAreceptors, inhibiting GABA-induced currents inX. laevisoocytes expressing these receptors (IC50= 5.02 μM).3Plasma levels of 5β-DHP decrease at the onset of spontaneous human labor.4

Pro8-Oxytocin是一种改良的OXT配体。在灵长类动物OXTR中，Pro8-Oxytocin比标准哺乳动物OXT配体Leu8-Oxytocin诱发更强效的反应和显著的行为影响。相较于Vasopressin (AVP)，Pro8-Oxytocin对人类AVPR1a的活性较低，但对狨猴AVPR1a的激活作用则高于AVP。

Lysipressin ([Lys8]-Vasopressin) 是一种抗利尿激素，从猪身上发现，能够诱发兔膀胱平滑肌的收缩，激活腺苷酸环化酶。

Oxytocin acetate (α-Hypophamine acetate) 是哺乳动物的神经垂体激素，是多效的下丘脑肽，是催产素受体的配体，有助于分娩、哺乳和亲社会行为。它可作为一种压力应对分子，具有抗炎、抗氧化剂和保护作用。

PF3274167 (Cligosiban) 是一种有效的、选择性的、高亲和力的非肽催产素受体拮抗剂。

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin，是一种催产素受体拮抗剂，可消除 CA1 锥体神经元中催产素增强的抑制性突触后电流。

Oxytocin parallel dimer is the disulfide-bridged homo peptide dimer.

TC OT 39是一种催产素类似物和OXTR(催产素受体)的选择性激动剂 (EC50=180 nM)，也是一种V1aR（加压素1a受体）拮抗剂，在小鼠模型中能够模拟催产素诱导的抓挠。

L 365209 is an oxytocin antagonist.

Epelsiban Besylate is an oral drug that is a highly selective anamol oxytocin receptor antagonist.

OT antagonist 1 is a potent and selective antagonist of Oxytocin(Ki of 50 nM)

Atosiban acetate (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。

OT antagonist 3 is an antagonist of oxytocin (OT).

[Arg8]-Vasotocin is a hormone present in the neurohypophysis of nonmammalian vertebrates that is related to vasopressin and oxytocin.

L 366682 is an oxytocin antagonist.

L-371,257 是催产素受体的竞争性拮抗剂，pA2 为 8.4，Ki 为 19 nM。 L-371,257 对加压素受体 1a 的 Ki 值为 3.7 nM。

Oxytocin free acid, also known as 9-Deamidooxytocin, is an analog of oxytocin where the glycinamide residue at position 9 has been substituted with a glycine residue. Oxytocin, a pleiotropic peptide hormone, has wide-ranging implications for general health, adaptation, development, reproduction, and social behavior.

[Glu4]-Oxytocin is a suitable derivative of oxytocin for conducting a thorough investigation, utilizing various methods, into the conformation of "oxytocin-like" molecules in aqueous solution.

(E/Z)-OT-R antagonist 1 是OT-R antagonist 1 的E/Z构型混合物。作为一种新型有效的选择性非肽类OT-R拮抗剂，它能抑制催产素诱导的细胞内Ca2+活动，IC50为8 nM。

SSR126768A 是一种新型且具有选择性、口服活性和有效性的催产素(OT)受体拮抗剂，对子宫收缩有抑制作用，可用于预防早产。

OT antagonist 3 analog is an analogue of OT antagonist 3.

'(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT)' 是催产素受体的一种拮抗剂，主要应用于神经系统疾病的研究领域。

SHR1653 is a highly potent, selective and brain penetrated antagonist of oxytocin receptor (OTR)(IC50 of 15 nM for hOTR).

WAY-267464是一种非肽的催产素受体(Oxytocin Receptor)激动剂，能够作为抗利尿激素(vasopressin)1A受体拮抗剂以损害大鼠的社会认知,可用于研究精神障碍。

OT-R antagonist 2 is a nonpeptide low molecular weight antagonist of OT-R .

Demoxytocin为一种异源性环肽，属于催产素类似物。其通过影响细胞膜通透性，提升平滑肌细胞内钙离子含量，进而加强平滑肌细胞收缩力，具备刺激子宫平滑肌收缩的能力，发挥催产素功能。此外，Demoxytocin在研究早产破裂引发的分娩刺激中有应用。

LIT-001 是非肽类催产素受体激动剂，EC50为55 nM，Ki 为226 nM。它可改善孤独症小鼠模型的社交互动。

Epelsiban is a selective and orally bioavailable oxytocin receptor antagonist (pKi: 9.9 for human oxytocin receptor).

[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity.