Endogenous Metabolite

Emopamil 作为一种钙通道抑制剂，其能有效减轻由缺血所导致的神经细胞损伤。

N-Lactylleucine为一种内源性代谢产物，常见于中间型枫糖尿病患者体内。

N-Lactylvaline 在中间型枫糖尿病患者的体内作为一种内源性代谢物存在，能通过检测确认其存在。

Hydantocidin 是一种腺苷琥珀酸合成酶抑制剂和螺旋呋喃糖，由Streptomyces hygroscopicus产生，对一年生、二年生和多年生杂草具有强效的除草活性。

Inosine 5’-diphosphate sodium ，一种含肌苷核碱基的嘌呤核糖核苷 5’-二磷酸盐，主要参与细胞的能量代谢和信号传递过程。

Phomosine D 是来自Phomopsis 的真菌代谢产物。

Gluconapin 是萝卜硫素的前体，而萝卜硫素是一种有效的抗癌异硫氰酸酯。Gluconapin 可降低小鼠因摄入玉米油而导致的血浆甘油三酯水平的升高。

ε-Caprolactone 是一种内酯化合物，可以从北极荆棘中提取。

Cystocholic acid 是一种胆汁酸的代谢产物，具有抗菌作用潜力。

Fluorocurarine chloride (Metvine; Vincanine methyl chloride) 是从长春花提取的一种植物代谢物。

(5α)-3,6-Dioxocholan-24-oic acid 是次级胆汁酸。

N-Cholyl-L-alanine 是一种在人体粪便样本中发现的胆汁酸酰胺。

Protoporphyrin IX disodium 作为辐射敏化剂，在缺氧环境下能有效增强 ROS 的生成并诱导 DNA 损伤。作为光敏剂，该化合物在光照射下可经历光漂白反应直接降解。此外，Protoporphyrin IX disodium 能在大鼠肿瘤细胞中通过给药 5-aminolevulinic acid (5-ALA) 形成并积累。在 405 nm 波长的红色荧光激活下，它可有效改善基底细胞癌的病情。Protoporphyrin IX disodium 在声动力和光动力疗法中对治疗膀胱癌和结节性基底细胞癌具有研究潜力。

Epothilone C 是一种聚酮类天然产物，由多酶系统中的一个非核糖体肽合成酶 (NRPS) 和九个多酮合成酶 (PKS) 分子共同合成。Epothilone C 可用于肿瘤研究。

PD-147693 (compound II) 是多巴胺自身受体 (presynaptic dopamine autoreceptor) 激动剂CI-1007的活性代谢物，并具有与CI-1007相似的抗精神病活性。

Aestivophoenin A 是一种微生物代谢物，具有神经元细胞保护作用。

iso-C15:0 3-OH 是种脂肪酸，能够从 PLRT 菌株中分离。PLRT 是一种革兰氏染色阴性的杆状细菌，属化学有机营养、异养、严格需氧型，可从软体动物 Aplysia punctata 的粪便中获取。

1-Oleoyl-2-linoleoyl-rac-glycerol (DG(18:1/0:0/18:2)) 是一种由亚油酸和油酸组成的二酰甘油。1-Oleoyl-2-linoleoyl-rac-glycerol 可在干腌火腿中找到，并作为食品风味剂使用。

4-Amino-3-hydroxyphenylalanine (4-AHP) 是真黑素的光降解产物，可用于研究皮肤黑色素瘤的形成和老年性黄斑变性。

3-Oxochenodeoxycholic acid 是一种内源性代谢物，存在于粪便中。它可以作为某些疾病（如 COVID-19）的诊断指标。

11β-Hydroxy-17α-methyltestosterone是17α-methyltestosterone的代谢产物。

Decarestrictin M 是从青霉菌菌株中分离获得的一种十烷内酯，具有胆固醇生物合成抑制剂的功能。

Cortodoxone-d7 (11-Deoxycortisol-d7) 是氘代的Cortodoxone。Cortodoxone (11-Deoxycortisol; cortexolone) 属于糖皮质激素类固醇激素，亦为糖皮质激素拮抗剂。此化合物可增加色氨酸加氧酶 (TO) 的活性，并促使皮质酮分泌，还参与调节 T 细胞的增殖和活化。

Dipivefrin is a prodrug of epinephrine, and is used to treat open-angle glaucoma.

Meluadrine tartrate is an endogenous metabolite.

Cyclopenol 是一种天然化合物，可作为天然产物对照品，其 CAS 号为 20007-85-6。

Secaubryenol is a 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla.

Coproporphyrin III is a derivative of porphyrin.

L-hydroxylysine dihydrochloride , is formed by posttranslational hydroxylation of some lysine residues. It is an amino acid, is exclusive to collagen protein.

NCX 1000 is a liver-specific NO donor compound,NCX 1000 derived from ursodeoxycholic acid (UDCA).

(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

Cellobiosan is an anhydro sugar formed during biofuel production from the fast pyrolysis of wood.

5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate. There are no literature reports of the biological activity or further metabolic fate of 5(S)-HETrE.

1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid and adrenic acid at thesn-1 andsn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus.1 1.Hancock, S.E., Friedrich, M.G., Mitchell, T.W., et al.Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespanLipids50(9)861-872(2015)

Setosusin is a meroterpenoid fungal metabolite originally isolated from C. setosus. It reduces neurotoxicity induced by amyloid-β (Aβ) aggregates in PC12 cells (EC50 = 112.6 μM). In vivo, setosusin (30 mg/kg) induces tremors in mice.

9(R)-HODE is one of several monohydroxylated products of linoleic acid. All known mammalian lipoxygenases appear to catalyze the oxygenation of arachidonic and linoleic acid to give products having strictly the (S) configuration at the site of oxygen insertion. However, both human umbilical vein endothelial cells and bovine aorta endothelial cells have been shown to produce 9(R)-HODE when incubated with linoleic acid. The physiological function of 9(R)-HODE and the enzyme that catalyzes its formation have not been determined.