Adrenergic Receptor

(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol , which is a metabolite of propranolol. The apparent half-life of (±)-4-hydroxy propranolol β-D-glucuronide is similar to propranolol and 4-hydroxy propranolol. Propranolol is a β-adrenergic antagonist, and the active enantiomer, (S)-(-)-propranolol , has log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.

5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 μM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5(6)-EET is provided as a mixture of the free acid and lactone.

Indacaterol xinafoate is an ultra-long-acting beta-adrenoceptor agonist.

Indoramin (hydrochloride) is a novel antihypertensive agent that exhibits selectivity for the α1A-adrenergic receptor.

BU-E 75 is an agonist of the histamine H2.

Etoperidone hydrochloride is an antidepressant agent.

Delequamine HCl is a potent and selective alpha 2-adrenoceptor antagonist. Delequamine HCl has a pKi of 9.45 for alpha 2-adrenoceptors in the rat cortex (pA2 in the guinea-pig ileum of 9.72).

Metaraminol is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors.

Solabegron (GW-427,353), is a selective agonist of β3 adrenergic receptors. In addition, Solabegron has been shown to produce visceral analgesia by releasing somatostatin from fat cells.

Dipiproverine 是α-氨基酸酯类化合物，是一种解痉化合物。它被用作抗胆碱能药物。

L-771688 is an α1A-adrenoceptor antagonist potentially for the treatment of benign prostatic hyperplasia.

KUL-7211 is an β2 and β3 adrenergic receptor agonist. KUL-7211 is a potent ureteral relaxant with a relatively small hypotensive effect.

FMS586 is a selective antagonist of neuropeptide Y Y5 receptor with oral activity.

Guanadrel Sulfate is a postganglionic adrenergic blocking agent. The uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter.

Fiduxosin hydrochloride is an alpha 1a-adrenoceptor antagonist that may be useful in the treatment of Benign Prostatic Hyperplasia.

Colterol (free base) is a short-acting β2-adrenoreceptor agonist. Bitolterol, a prodrug for colterol, is used in the management of bronchospasm in asthma and chronic obstructive pulmonary disease.

Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]benzoic acid – that is, the methyl group at the benzene ring is oxidized to a carboxyl group –, of which 88% are eliminated renally within 24 hours.

Arnolol is a beta blocker. Beta blockers block the hormone epinephrine, also known as adrenaline. This causes the heart to beat more slowly and with less force, thereby reducing blood pressure. Beta blockers also help blood vessels open up to improve blood flow.

Arrestin-3 modulator-1 (Compound LSH-3) 是一种用于调节 Arrestin-3 的化合物。它通过与 Arrestin-3 的域间界面结合，增强 Arrestin-3 在细胞中的磷酸化缺陷型β2AR的募集能力，同时提高 FRET 水平。该化合物适用于视网膜变性、甲状腺功能亢进以及肥胖等先天性疾病的研究。

Dehydro silodosin (KMD-3241) 是 α1A-肾上腺素受体（α1A-adrenoceptor）的选择性拮抗剂，用于研究良性前列腺增生。

Chloroguanabenz (acetate) 是胍那苄的衍生物，是一种抗朊病毒剂和 α2-肾上腺素受体激动剂。它在酵母和哺乳动物的体外试验中能够抑制朊病毒的形成，并降低 HEK293T 细胞中截短型亨廷顿蛋白衍生物 Htt48 的水平。Chloroguanabenz (acetate) 可用于亨廷顿舞蹈症的研究。

Taprizosin（UK-338003）是一种具有选择性和口服活性的 α1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，可用于舒张血管，用于治疗良性前列腺增生症。

ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) 是促肾上腺皮质激素的片段，可调节皮质醇和雄激素的产生。促肾上腺皮质激素 (ACTH)，也称为促肾上腺皮质激素，由垂体前叶产生和分泌。作为对生物应激的反应，ACTH 是下丘脑-垂体-肾上腺轴的重要组成部分。

Vadocaine (Vadocaina) 是一种新型的镇咳化合物，可用于局部麻醉，可用于研究中枢神经系统和心血管系统。

Faxeladol 是一种有效的肾上腺素能吸收抑制剂和 5-羟色胺重摄取抑制剂，是一种小分子 Opioid receptors激动剂，可用于研究神经系统疾病。

T-0509 是一种选择性 beta 1 受体激动剂，可增加犬心室肌的肌力，选择性下调大鼠心脏 β 1-肾上腺素受体。

Labetalone hydrochloride 是一种口服有效的肾上腺素能受体阻断药物，对 α 和 β 受体部位都有竞争性拮抗作用。

Amitriptyline-d6 Hydrochloride 是 Amitriptyline Hydrochloride 的氘代化合物。Amitriptyline Hydrochloride 的 CAS 号为 549-18-8。Amitriptyline hydrochloride 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA和TrkA受体的激动剂，具有强神经营养活性和有抗抑郁作用。

Fenoterol-d6 Hydrobromide 是 Fenoterol Hydrobromide 的氘代化合物。Fenoterol Hydrobromide 的 CAS 号为 1944-12-3。Fenoterol hydrobromide 是一种拟交感神经剂，是一种选择性的，具有口服活性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂，是一种有效的支气管扩张剂，可用于一种与哮喘、支气管炎和其他阻塞性气道疾病相关的支气管痉挛。

Nebivolol hydrochloride (Standard) 是 Nebivolol hydrochloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。

Tulobuterol-d9 HCl 是 Tulobuterol HCl 的氘代化合物。

Mabuterol hydrochloride (Standard) is the standard substance of Mabuterol hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Mabuterol hydrochloride is a selective β2 adrenoreceptor agonist. Mabuterol has a specific effect on beta 2-adrenoceptors with no beta 1-stimulation.

Xylometazoline hydrochloride (Standard) 是 Xylometazoline hydrochloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Xylometazoline hydrochloride (Xylometazoline HCl) 是一种 α- 肾上腺素受体激动剂，是一种鼻血管收缩药。

Acepromazine-d6 maleate 是 Acepromazine maleate 的氘代化合物。Acepromazine maleate 的 CAS 号为 3598-37-6。Acepromazine maleate 是一种 α 肾上腺素受体 (alpha-adrenoceptor) 拮抗剂，是一种吩噻嗪类促进安定的试剂。

Detomidine hydrochloride (Standard) 是 Detomidine hydrochloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Detomidine hydrochloride (MPV-253 AII) 是咪唑衍生物，是有效的 α2-肾上腺素能 (α2-adrenergic) 激动剂，可用于促进安定、缓解疼痛的研究。

Ritodrine hydrochloride (Standard) 是 Ritodrine hydrochloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Ritodrine hydrochloride (NSC 291565) 是一种 β-2肾上腺素受体激动剂。