Antibacterial

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.

Streptimidone, a metabolite produced by Streptomyces, exhibits various biological activities, including inhibiting protein synthesis at 50 µg/ml in cell-free assays and reducing tumor growth in rat xenograft models of H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma at daily doses of 12.5 and 25 mg/kg.

Terbinafine-d3 hydrochloride 是 Terbinafine hydrochloride 的氘代化合物。Terbinafine hydrochloride 的 CAS 号为 78628-80-5。Terbinafine hydrochloride 具有抗真菌感染活性。它是念珠菌属的角鲨烯环氧化酶的非竞争性抑制剂，Ki值为 30 nM。它还对某些革兰氏阳性和革兰氏阴性细菌具有抗菌活性。

17(R)-Resolvin D4 (17(R)-RvD4) is an epimer of RvD4, generated through the aspirin-induced modification process.

β-Gal-NONOate 为一种依赖β-半乳糖苷酶活化的一氧化氮(NO)供体，能够在β-半乳糖苷酶作用下释放NO。此化合物展现出杀菌活性，适用作为杀菌剂。

Rifaximin-d6 是 Rifaximin 的氘代化合物。Rifaximin 的 CAS 号为 80621-81-4。Rifaximin是一种胃肠道选择性抗生素，与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合，抑制细菌 RNA 合成。与革兰氏阴性菌（MIC：8-50 毫克/毫升）相比，它对革兰氏阳性菌株（MIC：0.03-5 毫克/毫升）的敏感性更高。

N-3-hydroxyoctanoyl-L-Homoserine lactone, a small diffusible signaling molecule secreted by various bacteria, plays a critical role in quorum sensing—a regulatory system used by bacteria to control gene expression according to cell density changes. This compound is generated via lactonolysis from 3-oxooctanoyl-homoserine lactone and can either activate or suppress gene expression and biofilm formation. Its production and function vary within the bacterial population growth phases, consequently mediating distinct cellular effects through alterations in gene expression, hence contributing to either quorum sensing or quenching.

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

Bassianolide, a cyclodepsipeptide insecticide produced by the fungal species B. bassiana and V. lecanii, demonstrates significant biological activity. Upon oral administration, it induces atony in B. mori silkworms at a concentration of 4 ppm and becomes lethal when concentrations exceed 8 ppm. Remarkably, atony in silkworm larvae can also be triggered by doses as low as 2 µg/larva. Further studies reveal that bassianolide (0.01-1 µM) specifically targets muscarinic receptors to inhibit contractions in isolated guinea pig smooth muscle tissue, elicited by acetylcholine, without affecting nicotinic receptor-induced contractions.

Maximin 4, 源自Bombina maxima皮肤分泌物的抗菌肽，展现对肿瘤细胞的细胞毒性及杀精效应。

Rosoxacin (Acrosoxacin) 是具有口服活性的喹诺酮类抗生素，具有广谱的抗菌活性，抑制革兰氏阴性菌，包括淋病奈瑟氏球菌(MIC90=0.03 mg/ml)。它在尿路感染中有应用的潜能。

Tosufloxacin tosylate hydrate (A-61827 tosylate hydrate) 是一个氟喹诺酮类抗菌剂。

Terbutaline Sulfate (Terbutaline hemisulfate) 是一种具有口服活性的 β2-肾上腺素能受体激动剂，是班布特罗的活性代谢物。它可研究哮喘。

Oxychlororaphine (phenazine-1-carboxamide) 强烈抑制 Streptomyces sp. 411 的生长。

3-Formyl rifamycin 是 Rifampicin 的分解产物，具有抗菌活性。

Topoisomerase IV inhibitor 2(compound 5d)是一种有效的Topo IV抑制剂，对Topo IV和DNA促旋酶的IC50分别为0.35 μM和0.55 μM，具有抗菌活性。

Aurein 2.4为一种抗菌肽，对革兰氏阳性细菌显示出抗生素活性。

BC-7013 是一种新型胸膜植物素，具有抗菌活性，抑制革兰氏阳性病原菌 (bacteria) 活性，可用于研究皮肤和呼吸道感染。

Butylparaben (Butyl 4-hydroxybenzoate) 是一种标准化的化学过敏原，可增加组胺释放和细胞介导的免疫。

L-K6L9 对于囊性纤维化患者的铜绿假单胞菌 (P. aeruginosa) 表现出显著的抗菌 (antimicrobial) 活性和抗生物膜 (anti-biofilm) 能力。该化合物的抗酶解性质保证了其在体内的稳定性，且不引发细菌的耐药性。

Trimosulfa是trimethoprim和sulfamethoxazole的混合物和抗生素组合，sulfamethoxazole抑制二氢叶酸合成酶（dihydropteroate synthase），trimethoprim抑制二氢叶酸还原酶（dihydrofolate reductase），用于轻度至中度细菌感染，对许多革兰氏阴性菌和阳性菌都有效。

Cefazolin 是一种头孢类抗生素, 用于多种细菌感染的研究。

DATPT 是一种小分子 12WLVSKF17 肽模拟分子。DATPT 抑制 SNX9-p47phox 相互作用，抑制活性氧和炎性细胞因子的产生。DATPT 具有抗炎和抗菌活性，通过减少 ATP 的产生发挥作用。DATPT 是治疗脓毒症的潜在化合物。

DuP 105是可口服的oxazolidinone类化合物，这是一种新型合成的抗菌化合物，对革兰氏阳性细菌具有有效性。

Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1 and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).

Antibacterial agent 64 是一种强效YycG 抑制剂 (IC50=6.1 µM) 和抗菌剂。Antibacterial agent 64 与氨苄西林联合使用可协同根除生物膜内的活菌。

Metioprim is a competitive bacterial dihydrofolate reductases inhibitor.

Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。

PAβN dihydrochloride (MC-207,110 dihydrochloride) 是一种外排泵抑制剂。

3beta,7beta,15beta-trihydroxy-11-oxo-lanosta-8-en-24->20 lactone is a natural product

Virstatin是一种新型抗病毒药物，是一种有效的病毒复制抑制剂，已被证明对多种病毒有效，包括单纯疱疹病毒（HSV）、人类免疫缺陷病毒（HIV）和流感病毒等。

Actinomycin X2 (Actinomycin V) is a compound synthesized by various species of Streptomyces. It displays potent inhibition against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 0.25 μg/mL. Actinomycin X2 possesses potential applications in the treatment of both cancer and bacterial infections.

Antibacterial agent 100 (Compound 7c) 是一种抗细菌和真菌剂，能够作用于 Staphylococcus aureus (MIC: 4 μg/mL)、Candida albicans (MIC: 4 μg/mL) 和 Cryptococcus neoformans (MIC: 8 μg/mL)。

AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens. IC50 value: 2-4 ug/ml (MICs) Target: antibacterial agent AVX13616 was as active as mupirocin i

Djenkolic Acid (S,S'-Methylenebiscysteine) 是天然存在于东南亚植物 Archidendron jiringa 的 Djenkol 豆中的含硫非蛋白质氨基酸。它是人类急性肾损伤的一个不常见但重要的原因。

DZ2002 是一种口服有效的、可逆的、低细胞毒性的 III 型 SAHH 抑制剂 (Ki=17.9 nM)，具有较好的免疫抑制活性。DZ2002 能通过逆转各种细胞类型的促纤维化表型来防止实验性皮肤纤维化的发展。DZ2002 可用于自身免疫性疾病，如狼疮综合征和系统性硬化症的研究。