Apoptosis

Linearol is a diterpene found in Sideritis L. spp. (Lamiaceae) with a broad range of demonstrated properties including antioxidant, anti-inflammatory, and anti-apoptotic activities.

A-1208746，一种MCL-1抑制剂，其Ki值为0.454 nM。该化合物能够激活caspase-3/-7，诱发H929细胞的细胞凋亡(apoptosis)，并降低线粒体膜电位。此外，A-1208746与Navitoclax共同使用时，可以在癌症研究中发挥协同效应。

Emavusertib (CA-4948) hydrochloride，作为一种选择性、有效且口服活性的IRAK4/FLT3抑制剂，在FRET激酶测定中对IRAK4展示出57 nM的IC50值，且表现出抗肿瘤活性。

5-Methoxyflavanone is a natural product

Myristoleic Acid Methyl Ester is a natural product.

Ub4ix 是DUB/26S 蛋白酶体 (26Sproteasome) 的一种抑制剂，能够防止 K48 连接的 Ub 链被去泛素化酶 (DUBs) 切割，从而避免了 Ub 标记蛋白的蛋白酶体降解。此外，Ub4ix 在降低 Hela 细胞的活性及诱导细胞凋亡 (apoptosis) 方面表现出效力，其 IC50 值为1.6 μM。

ATWLPPRAANLLMAAS 是一种嵌合肽，具备显著的抗血管生成和抗肿瘤作用。它能够抑制人肝细胞癌细胞的增殖、活力、迁移和侵袭，同时诱导细胞凋亡 (apoptosis)。

Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.

CSF1R-IN-26 (Compound III-1) 是一种CSF-1R抑制剂，其IC50为20.07 nM。CSF1R-IN-26 能促进M2型巨噬细胞向M1型极化，从而诱导MC-38癌细胞发生凋亡 (apoptosis)。该化合物抑制AKT/ERK/STAT3信号通路的激活，并重塑肿瘤免疫微环境，在小鼠模型中表现出显著的抗肿瘤活性。CSF1R-IN-26 在SD大鼠中显示出良好的药代动力学特性，其半衰期为1.86小时，口服生物利用度达到79.22%。

Maytansinol (GMP)是 Maytansinol 的 GMP 级别试剂。Maytansinol 是一种在体外抑制微管组装并导致微管分解。它与辐射联用，用于果蝇和人类癌细胞。

Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treating drug-resistant gastric cancer cells, especially when used in combination with SN38, PTX, or VP16. The apoptosis process might be the main mechanism underlying the synergistic effect of these combinations. The ERCC1 and p53 genes may play an integral role in the synergism between Ki23057 and chemotherapeutic agents in drug-resistant cell lines. (source: Cancer Lett. 2011 Aug 1;307(1):47-52).

MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM and NHL cell lines and patient cells. Examination of signaling events after treatment showed time-dependent decrease in levels of the notch intracellular domain, Hes1 and c-Myc. MRK003 downregulated cyclin D1, Bcl-Xl and Xiap levels in NHL cells and p21, Bcl-2 and Bcl-Xl in MM cells. In addition, MRK003 caused an upregulation of pAkt, indicating crosstalk with the PI3K/Akt pathway.

KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumor growth in human HT29 colorectal cancer and NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice. This molecule should serve as a useful lead for inhibitors targeting kinases and may lead to new therapeutics for the treatment of cancer. (source: Invest New Drugs. 2012 Apr;30(2):518-23. doi: 10.1007/s10637-010-9584-2. Epub 2010 Nov 16. ).

Casuarinin is an ellagitannin. It is found in the pericarp of pomegranates. It is also found in Casuarina and Stachyurus species and in Alnus sieboldiana. It is an isomer of casuarictin. It is a highly active carbonic anhydrase inhibitor. It is a compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions.

Aspirin calcium is the prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

Avotaciclib sulfate is a cyclin-dependent kinase inhibitor and antineoplastic.

BP-1-108 is a potent and selective STAT5 inhibitor.

Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.

Cidofovir sodium is the salt form of Cidofovir, a Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor that is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis in people with AIDS. The mechanism of action of cidofovir is as a DNA Polymerase Inhibitor. The chemical classification of cidofovir anhydrous is Nucleoside Analog.

NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.

Eps8 peptide 327 是一种从 Eps8 蛋白衍生的 HLA-A*2402 限制性肽抗原。它表现出强效抗肿瘤活性和显著的细胞毒性，通过有效抑制癌细胞增殖和诱导细胞凋亡 (apoptosis)，并通过抑制如 IL-2、TNF-α 和 IFN-γ 的下游信号表达及破坏 Eps8/EGFR 相互作用来影响 EGFR 信号通路。Eps8 peptide 327 在 HT-29 异种移植模型中显著抑制肿瘤生长。

RP-220 是一种针对NLRP3的肾素酶肽，具有抗炎和抗凋亡特性。此化合物通过激活MAPK信号通路来抑制碱性损伤导致的肾小管上皮细胞凋亡 (apoptosis)。在急性肾损伤 (AKI) 小鼠模型中，RP-220 显著减少NLRP3的表达，并降低巨噬细胞浸润和肾脏组织损伤的程度。RP-220 可用于系统性红斑狼疮 (SLE) 及其并发症狼疮性肾炎 (LN) 的研究。

AKR1B1/STAT3/SLC7A11-regulator-1 (5a) 是一种作用于AKR1B1/STAT3/SLC7A11的调节剂，通过增强铁凋亡 (apoptosis) 的活性来逆转 MCF-7/ADR 细胞对DOX的耐药性。AKR1B1/STAT3/SLC7A11-regulator-1 适用于乳腺癌的研究。

FLT3-IN-32 是一种高效选择性的FLT3抑制剂，能够有效抑制FLT3的激活突变并诱导细胞凋亡 (apoptosis)。在无肿瘤小鼠中，FLT3-IN-32 展示了良好的耐受性，而在负荷 MV4-11 细胞的 NOD/SCID 小鼠模型中，该化合物显现出卓越的抗肿瘤效果，并能显著延长小鼠的生存期。FLT3-IN-32 适用于急性髓系白血病的研究。

I3IN-002是一种小分子IGF2BP3抑制剂，IC50值在 SEM 细胞中约为 2 μM。该化合物能够干扰与m6A修饰的mRNA的相互作用，破坏目标基因（如CDK6、MYC和BCL2）的稳定性，进而抑制白血病细胞生长，诱导细胞周期停滞，并促进细胞凋亡。I3IN-002有潜力用于B细胞急性淋巴细胞白血病的研究。

MAPK-IN-5 是一种高效的MAPK抑制剂，其对HeLa细胞的IC50值为1.35 μM。MAPK-IN-5 能通过MAPK途径诱导ROS介导的DNA损伤和线粒体凋亡 (apoptosis)，显著抑制HeLa细胞的集落形成，减少活细胞数量，并抑制细胞迁移，阻碍细胞周期在G2/M期。MAPK-IN-5 可以用于宫颈癌研究。

Picolinafen 是一种抑制八氢番茄红素去饱和酶 (PDS) 的吡啶类除草剂，能够控制阔叶杂草和干扰类胡萝卜素的合成。它对猪胚胎滋养外胚层细胞 (pTr) 和子宫腔上皮细胞 (pLE) 展现细胞毒性，能够诱导ROS积累、钙离子耗竭，并激活MAPK和PI3K信号通路，导致细胞活力降低，促进凋亡 (apoptosis)，影响迁移能力，并改变着床相关基因的表达。Picolinafen 可削弱 pTr 和 pLE 的着床能力。其对哺乳动物的LD50值为 2.7 mg/kg，对鱼类为 7 μg/L，并在斑马鱼胚胎发育中展现毒性效应。

ZG-2492是一种口服有效的LDHA抑制剂，IC50为156 nM。它能够减少胰腺癌细胞中的乳酸生成，并诱导细胞周期阻滞和凋亡 (apoptosis)。ZG-2492具有抗肿瘤活性，可应用于胰腺癌等肿瘤的研究。

γ-Eudesmol ((+)-γ-Eudesmol) 是一种能介导线粒体诱导凋亡的化合物。其通过与线粒体膜蛋白结合导致膜电位去极化，并激活半胱氨酸天冬氨酸蛋白酶级联反应。γ-Eudesmol 对多种肿瘤细胞系 (如 HepG2、B16-F10) 显示出细胞毒性，IC50值为 8.86-15.15 μg/mL，可能在肝细胞癌和黑色素瘤等癌症研究中具有应用潜力。

Citric acid-13C2 是含 13C 标记的 Citric acid。作为一种防腐剂和食品添加剂，Citric acid 可诱导 HaCaT 细胞发生凋亡 (apoptosis)，并导致细胞周期在 G2/M 期和 S 期阻滞。此外，Citric acid 通过降低抗氧化酶活性引发肝脏的氧化损伤。它也是一种常用于多种行业的酸化剂、乳化剂、螯合剂和缓冲剂。

HI042 是一种 FMS 类酪氨酸激酶 3 (FLT3) 抑制剂。其在 MOLM-13 细胞中的 IC50 值为 0.62 μM，在 MV4-11 细胞中的 IC50 值为 0.33 μM，在 OCI-AML3 细胞中的 IC50 值为 0.89 μM。HI042 能选择性降低 FIT3-内部串联重复突变 (FLT3-ITD) 阳性细胞系的存活率，诱导细胞凋亡 (apoptosis)，干扰细胞周期，并降低集落形成能力。该化合物可用于急性髓系白血病 (AML) 的研究。

Tuspetinib (HM43239) dihydrochloride 是一种可口服的选择性FLT3抑制剂，IC50值为 1.1 nM (FLT3野生型)、1.8 nM (FLT3-ITD 突变型) 和 1.0 nM (FLT3-D835Y 突变型)。作为可逆的 I 型抑制剂，它直接抑制FLT3的激酶活性，并调节p-STAT5, p-ERK、SYK、JAK1/2及TAK1。Tuspetinib dihydrochloride 还能够抑制白血病细胞的增殖，并诱导细胞凋亡 (apoptosis)。

Apoptosis inducer40 是凋亡 (apoptosis) 诱导剂，对 Jurkat 细胞和 NB4 细胞具有显著细胞毒性，其IC50值分别为 4.5 μM 和 3.6 μM。Apoptosis inducer40 能诱导细胞凋亡及阻碍细胞周期，适用于急性髓系白血病 (AML) 等癌症研究。

Stigmast-5-en-3-ol 通过增加Bax、Caspase-9、p53和PARP裂解的产生，以及降低Bcl-xl表达，诱导癌细胞凋亡 (apoptosis) 和抑制增殖。它对葡萄糖淀粉酶和 α-淀粉酶 (α-amylase) 展现出强效抑制作用，且具备高抗氧化活性。Stigmast-5-en-3-ol 可用于研究白血病、乳腺癌、2 型糖尿病及肥胖症等疾病。

Apoptosis inducer42 是一种诱导凋亡的化合物，可以激活晚期凋亡并抑制IL-6的分泌。它对癌细胞表现出高细胞毒性，适用于癌症研究，如结肠癌。

(Z)-[2,3’-Biindolinylidene]-2’,3-dione 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64423，CAS号为 906748-38-7。