Apoptosis

Thalidomide-NH-amido-PEG2-C2-NH2 是一种合成的 E3 连接酶配体-linker 偶联物，由基于 Thalidomide 的 cereblon 配体和一个 linker 组成，适用于合成 PROTAC。

Thalidomide-O-PEG4-amine TFA 是一种合成的 E3 连接酶配体-linker 偶联物，由基于 Thalidomide 的 cereblon 配体和一个 linker 组成。

PBOX-15 is a novel microtubule-targeting agent that induces apoptosis, upregulates death receptors, and enhances TRAIL-mediated apoptosis in multiple myeloma cells. It also inhibits T cell migration through post-translational modification of tubulin. Pbox

Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, pro

CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.

N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.

Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis.

Enzastaurin HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin HCl selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.

BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator.

Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.

C1A is an inhibitor of HDAC6 which modulates downstream autophagy substrates and leads to growth inhibition of a diverse set of cancer cell lines.

MOTS-c为源于线粒体的多肽（MDP），它通过激活AMPK途径并抑制MAP激酶-c-fos信号通路，具有抗损伤和抗炎效应。

Uvaol diacetate (Compound 5)，一种从Nerium oleander L.叶提取的三萜化合物。

Anticanceragent 174 (BA-3) 是抗癌化合物。该化合物通过线粒体途径引发肿瘤细胞的apoptosis，有效抑制黑色素瘤小鼠异种移植瘤模型中的癌细胞增殖。

c-Fos-IN-1 (Compound P16) 是一种c-Jun抑制剂，能够降低c-Fos的mRNA和蛋白质水平，同时抑制ERK的磷酸化及AP-1的转录活性。它通过抑制ERK/c-Fos/Jun通路展现抗癌效果，减缓胃癌细胞（MGC-803）的增殖和迁移（IC50 2.31 μM），并使细胞周期停滞于G2/M期，诱导癌细胞凋亡，抑制胃癌肿瘤的生长。

RD-23 是一种口服活性和选择性的 RET PROTAC 降解剂，能够促进 RETG810C 突变的泛素化和降解，其 DC50 值为 11.7 nM。RD-23 可抑制 Shc 信号的下游激活并诱导细胞凋亡 (Apoptosis)，适用于 RET 相关癌症的研究。

CHI-KAT8i5 是一种高选择性的KAT8抑制剂，具有 19.72 μM 的 KD。它能以剂量依赖性方式引发凋亡 (Apoptosis)，并抑制食管鳞状细胞癌、结肠癌、黑色素瘤、胃癌、非小细胞腺癌及肝癌的肿瘤生长。

estrogen receptor modulator

WF-210 is an effective activator of procaspase-3 that acts by inducing apoptosis in cancer cells and reducing tumor growth.

06:0 PE (PE(6:0/6:0)) 是一种具有短酰基链的水溶性磷脂，其特点是具有抗肿瘤活性和能够抑制肿瘤在体内的发展。此外，它还展现出抗增殖和促进细胞凋亡的功能，并可作为磷脂酰胆碱与磷脂酰乙醇胺的前体。

Gallium 8-Hydroxyquinolinate 是一种有效的凋亡 (apoptosis) 诱导剂，能够通过诱导Ca2+信号转导来触发癌细胞的p53依赖性和非依赖性细胞凋亡。此外，其纳米结构展现出卓越的光学性能，使其在肿瘤研究领域具有重要应用价值。

GP130-IN-1（compound 49）是一种高度有效且选择性强的GP130抑制剂，展现出优越的体外抗癌活性，并相较于Bazedoxifene显示出更高的选择性。此化合物通过诱导细胞超微结构变化，导致细胞周期在G0/G1阶段因时间依赖性而阻滞，并触发细胞凋亡 (apoptosis) 及自噬 (autophagy) 进程。GP130-IN-1主要用于三阴性乳腺癌的研究领域。

p53-MDM2-IN-6, LSM-83177腙类似物，展现出显著的p53-MDM2抑制效果，其IC50值为11.08 µg/mL。该化合物能够诱导S期细胞周期阻滞以及早期与晚期的细胞凋亡 (Apoptosis)，在HT29细胞系表现出强烈的抗增殖性，IC50值为10.44 µg/mL。通过抑制p53-MDM2相互作用，p53-MDM2-IN-6可提升p-53水平并降低GST酶表达，显示其在结直肠癌研究中的潜力。

Acyclovir hydrochloride (Aciclovir)，一种口服抗病毒药物，展现出显著的抗疱疹效果。该化合物对HSV-1和HSV-2显示出较低的IC50，分别为0.85 μM和0.86 μM。此外，Acyclovir hydrochloride能够引起细胞周期的干扰及诱导凋亡 (apoptosis)。它还用于预防在急性白血病的诱导治疗中发生的细菌感染。

SILA-123，作为一种针对FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM) 的抑制剂，能有效地阻断FLT3的磷酸化及其下游信号通路，从而在 G0/G1 期阻止细胞周期的进展，并引发细胞凋亡 (apoptosis)。该化合物主要用于急性髓系白血病的研究。

PIK-C98 is an inhibitor of PI3K that acts by displaying potent preclinical activity against multiple myeloma.

(E/Z)-LAQ824 is an inhibitor of histone deacetylase.

Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis.

Rooperol is a norlignan derivative with numerous biological activities including immunomodulatory, antitumor, antibacterial, anticonvulsant, and antioxidant activities. It is a novel p38α inhibitor.

ABD56 inhibits osteoclast formation and activity in vitro and in vivo.

Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad-spectrum caspase inhibitor, provides a cost-effective, non-toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new

2-Chloronaphthalene is an organochlorine chemical compound and is a chlorinated derivative of naphthalene. The compound is an isomer for 1-chloronaphthalene.

Emavusertib Tosylate（亦称CA-4948）是一种有效的IRAK4/FLT3抑制剂，具有抗肿瘤活性。在ABC DLBCL和AML细胞系中，CA-4948展现了良好的细胞活性。该化合物在329种激酶的评估中表现出中到高的选择性，并且在ADME和PK配置文件中展示出良好的口服生物利用度和优良的药代动力学特性。在小鼠、大鼠和狗的模型中，CA-4948展示了良好的口服生物利用性，并在相关肿瘤模型中显示出超过90%的肿瘤生长抑制效果，与体内PD调节具有极好的相关性。

E3 ligase Ligand 36为E3连接酶配体，专门用于PROTACs的合成，如PROTAC BRM/BRG1 degrader-1。

Antibacterialagent 254 (Compound 2) 是抗菌剂，可在浓度为 50 μM 的条件下去除 7 天龄的 P. aeruginosa 生物膜，同时不影响细菌的生长。此外，Antibacterialagent 254 还可增强 Ciprofloxacin 对 P. aeruginosa 的杀菌效果，同时提升基质降解酶基因 pelA、pslG 和 eddA 的表达水平。

DC-5163 is a potent inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with IC50 of 176.3 nM and Kd of 3.192 μM. DC-5163 selectively inhibits cancer cell proliferation and induces apoptosis, and partially inhibits the glycolysis pathway.