Prostaglandin Receptor

11-deoxy Prostaglandin E1 是前列腺素 E1类似物，具有支气管扩张活性，可抑制组胺诱导的支气管收缩，引起离体豚鼠的气管条松弛。

(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.

BI-671800 (AP-761) 是高特异性的前列腺素 D2 受体拮抗剂，对哮喘有研究潜力，对人和小鼠 CRTH2 转染细胞中 PGD2 结合 CRTH2 的 IC50值分别为 4.5 和 3.7 nM。

Butaprost 是一种选择性的前列腺素 E 受体 EP2 激动剂，对小鼠 EP2 受体的 EC50 为 33 nM、Ki 为 2.4 μM，而对小鼠 EP1、EP3 和 EP4 受体的活性显著较低。Butaprost 可通过抑制 TGF-β/Smad2 信号通路有效减轻纤维化反应，支持Butaprost 在纤维化、炎症及前列腺素受体信号研究中的应用。

Misoprostol acid, an active metabolite of Misoprostol, is used for treating non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers.

MK-447 is a nonsteroidal antiinflammatory agent.

Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Penduletin has strong activity in vitro against EV71 with low cytotoxicity.

CI-949 is an allergic mediator release inhibitor, which inhibits leukotriene C4/D4 (LTC4/LTD4), histamine, and thromboxane B2 (TXB2) release (IC50s: 0.5 μM, 11.4 μM and 0.1 μM).

Thromboxane B1 (TXB1) 是TXB家族中的一员，属于类花生酸脂质家族。该家族因参与血栓形成而得名。

Ralinepag (APD811) 是一种可口服的非前列腺素前列环素 (IP) 受体激动剂，对人和大鼠 IP 受体以及人 DP1 受体的 EC50 分别为 8.5、530 和 850 nM。

TCS 2510 (CAY10598) 是一种选择性 PGE2 和 EP4 受体激动剂，可增强细胞内 cAMP 浓度和活性 β-caten 的丰度。TCS 2510 抑制TNF-α 产生，可用于研究代谢紊乱带来的疾病。

11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs.

EP3 antagonist 4 是一种 EP3 拮抗剂，对 hEP 有抑制作用， Ki 值为 2 nM。EP3 antagonist 4 在大鼠完整 PK 研究中显示出较低的体内清除率、高口服 AUC 和良好的生物利用度。EP3 antagonist 4 可用于研究糖尿病和细胞功能障碍。

Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.

Droxicam (Droxicamum) 是一种非甾体抗炎化合物，可用于缓解肌肉骨骼疾病的炎症和疼痛的研究。

Vedaprofen (PM 150) 抑制 COX-1 并通过抗炎活性减少前列腺素 H2 的合成。 Vedaprofen 是一种大肠杆菌滑动钳抑制剂，IC50 为 222 μM，Ki 为 131 μM。

Fevipiprant (NVP-QAW039) 是一种选择性、强效、可逆的竞争性 CRTh2 拮抗剂，KD 值为1.1 nM，IC50为0.44 nM，能够引发人体嗜酸性粒细胞的形状变化。

Grapiprant (AAT-007) 是一种选择性EP4 受体拮抗剂，生理配体为前列腺素 E2(PGE2)，有用于骨关节炎疼痛和炎症的研究潜力。它取代 [3H]-PGE2(1 nM) 与狗的重组EP4 受体结合，IC50为 35 nM，Ki 为 24 nM。

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).

AAT-008 is a PGE2 receptor EP4 antagonist.

Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.

L 888607 Racemate is a selective antagonist of prostaglandin D2 receptor subtype 1 (DP1) (Kis: 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively).

AH 6809 是 EP 和 DP 受体的拮抗剂，对小鼠 EP2受体的 Ki 值为 350 nM，对克隆的人类 EP1，EP2，EP3-III 和 DP 受体的 Ki 值分别为 1217、1150、1597 和 1415 nM。

Quinotolast sodium inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner in the concentration range of 1-100 μg/mL.

Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacological studies on 15-keto-17-phenyl trinor PGF2α ethyl amide have been reported.

MK-7246 S enantiomer is a potent and selective CRTH2 antagonist.

Latanoprost acid 是前列腺素受体的选择性激动剂，通过抑制 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。 拉坦前列素酸可用于降低眼内压力的研究。

DBMB 是一种脾酪氨酸激酶 (Syk) 抑制剂，可有效抑制 Syk 激酶活性。它具有抗炎活性，通过抑制 NF-κB 的信号传导，减少炎症介质如一氧化氮 (NO) 和前列腺素 E2 (PGE2) 的产生。DBMB 可用于炎症性疾病的研究。

Latanoprosttris(triethylsilyl) ether 是 Latanoprost 合成的前体，它是前列腺素 F2α (PGF2α) 受体 (FP受体) 激动剂。

TASP0412098 is a potent, selective CRTH2 antagonist with oral activity.

15(S)-15-methyl Prostaglandin F2α methyl ester 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T36156，CAS号为 35700-21-1。

17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or unnatural" isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity

Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye.

15(R)-Prostaglandin D2作为一种潜在的前列腺素DP(2)受体激动剂，展现出抗炎活性。它能促进人嗜酸性粒细胞内肌动蛋白的聚合，同时提高血小板中的cAMP水平。

Lythrine ((+)-Lythrine) 是一种生物碱，最早从 H. salicifolia 中分离出来，可抑制前列腺素合成酶，其 IC50 为 469 μM。

(S)-AL 8810是PGF2α的11β-氟类似物，是一种FP受体的有效和选择性拮抗剂。(S)-AL 8810是AL 8810的C-15初聚物，相对于AL 8810，其C-15具有逆(S)或"自然"构型为15-(R)。